Porokeratosis
☆ Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Mae'r ymylon caled sy'n ymwthio allan yn nodweddiadol.
References
Mae Porokeratosis yn gyflwr croen prin a nodweddir gan broblemau keratinization, sy'n arwain at glytiau siâp cylch uchel neu lympiau garw ar y croen. Ei nodwedd ddiffiniol o dan y microsgop yw presenoldeb lamella cornoid, trefniant penodol o gelloedd yn haen uchaf y croen. Daw Porokeratosis mewn amrywiol ffurfiau (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Mae'n bwysig nodi y gall porokeratosis ddatblygu'n ganser y croen. Y ffordd orau o wneud diagnosis o porokeratosis yw trwy fiopsi o'r ffin uwch, er nad oes protocol triniaeth safonol ar hyn o bryd.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Mae Disseminated superficial actinic porokeratosis (DSAP) yn glefyd o geratineiddio anhrefnus. Mae'n un o chwe math o porokeratosis, ac fel arfer mae'n effeithio ar ardaloedd mwy o'i gymharu â'r lleill (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Mae'r math echdoriadol o porokeratosis yn aml yn cysylltu â chanser, imiwnedd gwan, neu lid. Mae ffactorau risg yn cynnwys geneteg, ataliad imiwnedd, ac amlygiad i'r haul. Mae DSAP yn dechrau fel lympiau pinc neu frown gydag ymylon uwch mewn mannau agored i'r haul, gan achosi ychydig o gosi weithiau. Mae triniaethau'n amrywio a gallant gynnwys hufenau amserol, therapi ysgafn, neu feddyginiaethau fel 5-fluorouracil neu retinoidau. Ystyrir bod y briwiau hyn yn gyn-ganseraidd, gyda siawns 7. 5 - 10 % o droi'n garsinoma celloedd cennog neu gelloedd gwaelodol.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Daeth dyn 52 oed, a oedd yn iach cyn hynny, i mewn gyda darn fflat, siâp cylch ar ddiwedd ei bedwerydd bys traed, a oedd wedi bod yno ers 2 flynedd heb achosi unrhyw symptomau. Dechreuodd fel twmpath bach, caled a thyfodd tuag allan dros amser. Er gwaethaf rhoi cynnig ar wahanol driniaethau fel cryotherapi, hufenau, gwrthffyngolau a gwrthfiotigau, ni wellodd y clwt. Wrth ei archwilio'n agos gyda dermocopi, gwelwyd canol sych, coch gyda border trwchus, garw. Roedd darn bach o groen a gymerwyd o ymyl y clwt yn dangos twf celloedd annormal yn haen allanol y croen, gan gadarnhau diagnosis o porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Yn aml, cynhelir biopsi oherwydd gall edrych yn debyg i keratosis actinig neu garsinoma celloedd cennog.