Syphilis - Syffilis
☆ Yng nghanlyniadau Stiftung Warentest 2022 o’r Almaen, roedd boddhad defnyddwyr â ModelDerm ond ychydig yn is nag ymgynghoriadau telefeddygaeth taledig.
Chancres ― haint syffilitig sylfaenol erbyn Treponema pallidum
References
Mae siffilis yn glefyd a drosglwyddir yn rhywiol a achosir gan y bacteriwm Treponema pallidum. Yn yr astudiaeth hon, rydym yn canolbwyntio ar 57 o gleifion 18-68 oed â siffilis eilaidd.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Mae syffilis yn haint bacteriol a achosir gan Treponema pallidum. Gall ddynwared afiechydon amrywiol, gan ennill y llysenw great imitator iddo. Mae siffilis yn dal i effeithio ar filiynau yn fyd-eang ond gellir ei drin yn effeithiol gyda phenisilin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Mae Treponema pallidum yn achosi siffilis trwy gyswllt rhywiol neu o'r fam i'r babi yn ystod beichiogrwydd. Er bod profion syml i wneud diagnosis ohono a bod triniaeth ag un ergyd penisilin hir-weithredol yn gweithio'n dda, mae siffilis yn dod yn broblem fawr eto ledled y byd. Mae hyn yn arbennig o wir ymhlith dynion sy'n cael rhyw gyda dynion (MSM) mewn gwledydd ag incwm uchel a chanolig. Er bod rhai gwledydd incwm isel wedi cyflawni nodau Sefydliad Iechyd y Byd i atal siffilis rhag mynd o'r fam i'r babi, mae cynnydd pryderus mewn siffilis ymhlith MSM HIV-positif.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Afu Chwyddo: Yn aml, canfyddir hwn a gall ddigwydd ochr yn ochr â dueg chwyddedig. Gall archwilio biopsi iau o dan ficrosgopeg maes tywyll ddatgelu presenoldeb y spirochete. Gall profion gweithrediad yr afu ddangos annormaleddau. (2) Melyn y Croen (Clefyd melyn) : Mae p'un a yw rhywun yn dangos clefyd melyn yn dibynnu ar faint yr effeithir ar yr afu/iau. (3) Trwyn Rhedeg: Yn aml un o'r arwyddion cyntaf, fel arfer o fewn yr wythnos gyntaf ar ôl genedigaeth. (4) Nodau Lymff Chwyddedig: Mae chwyddo cyffredinol mewn nodau lymff, fel arfer yn ddi-boen, hefyd yn gyffredin. (5) Brech y Croen: Mae brech fel arfer yn ymddangos wythnos i bythefnos ar ôl y trwyn yn rhedeg. Efallai y gwelwch smotiau bach coch neu binc ar y cefn, y pen-ôl, y cluniau a gwadnau'r traed. Gall y frech hon symud ymlaen i blicio a chrychu.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnosis a Thriniaeth
Gellir defnyddio VDRL ac RPR i gadarnhau haint diweddar a sgrinio am siffilis. Mae prawf FTA-ABS yn brawf mwy penodol a gellir ei ddefnyddio i wirio am hanes haint blaenorol. Defnyddir penisilin i drin siffilis.