Acanthosis nigricans
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Det er almindeligt hos overvægtige mennesker.
relevance score : -100.0%
ReferencesAcanthosis nigricans er en kutan manifestation af en underliggende tilstand. Den forekommer ofte i hudfolder som hals, armhuler og lyske og fremstår som fløjlsbløde, mørke pletter med uklare kanter. Tilstanden er typisk forbundet med diabetes og insulinresistens, men i sjældne tilfælde kan den indikere kræft i kroppen. Den kan også opstå som følge af hormonelle problemer eller ved brug af specifik medicin såsom steroider og p‑piller.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans is a cutaneous manifestation of an underlying condition. It usually develops in skin folds, such as the back of the neck, axilla, and groin, where it presents as velvety hyper-pigmented patches with poorly defined borders. Acanthosis nigricans is most commonly associated with diabetes and insulin resistance, but rarely it can be a sign of internal malignancy. It can also occur with hormone disorders or with the use of certain medications like systemic glucocorticoids and oral contraceptives.
Acanthosis nigricans (AN) er en almindelig hudlidelse, der er forbundet med forskellige sundhedsproblemer såsom insulinresistens, diabetes, fedme, visse kræftformer, hormonelle forstyrrelser og bivirkninger af medicin. Behandlingen af AN fokuserer på at håndtere de underliggende tilstande. Først undersøger lægen tegn på insulinresistenssyndrom, som omfatter fedme, forhøjet kolesteroltal, forhøjet blodtryk og type‑2‑diabetes. Læger ordinerer ofte topical retinoids som førstevalg, hvilket kan hjælpe med at reducere hudens fortykkelse, men de kan sjældent fjerne den mørke pigmentering fuldstændigt. Andre behandlingsmuligheder, herunder salicylic acid, podophyllin, urea og calcipotriol, kræver også hyppig påføring.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
Acanthosis nigricans (AN) is a common dermatologic manifestation of systemic disease that is associated with insulin resistance, diabetes mellitus, obesity, internal malignancy, endocrine disorders, and drug reactions. Treatment of AN primarily focuses on resolution of the underlying disease processes causing the velvety, hyperpigmented, hyperkeratotic plaques found on the skin. Initial considerations for the AN workup include evaluating patients for insulin resistance syndrome characterized by obesity, dyslipidemia, hypertension, and diabetes mellitus type II. For cosmetic treatment, topical retinoids are considered the first-line therapy for insulin-resistant AN by modifying keratinization rate. However, topical tretinoin requires application for long durations and improves hyperkeratosis, but not hyperpigmentation. Topical salicylic acid, podophyllin, urea, and calcipotriol also require frequent application, while TCA peels may provide a faster and less time-intense burden.
○ Årsager
Den forekommer hyppigst hos personer under 40 år, kan være arvelig og er associeret med fedme eller endokrinopatier, såsom hypothyroidisme, akromegali, polycystisk ovariesygdom, insulinresistent diabetes eller Cushings sygdom.
○ Behandling – OTC‑lægemidler
#40% urea cream