Acute generalized exanthematous pustulosis - Akut Generaliseret Eksanthematøs Pustulose
Akut Generaliseret Eksanthematøs Pustulose (Acute generalized exanthematous pustulosis) (AGEP) er en sjælden hudreaktion, som i 90 % af tilfældene er relateret til medicinindgivelse. Akut Generaliseret Eksanthematøs Pustulose (acute generalized exanthematous pustulosis) er karakteriseret ved pludselige hududbrud, der typisk opstår omkring fem dage efter, at en ny medicin er påbegyndt. Udslætterne består af pustler – små røde, hvide eller røde hududbrud, der indeholder uklart eller purulent materiale (pus). Hudlæsionerne forsvinder som regel inden for 1–3 dage efter, at den udløsende medicin er stoppet.
☆ I 2022 Stiftung Warentest-resultaterne fra Tyskland var forbrugernes tilfredshed med ModelDerm kun lidt lavere end med betalte telemedicinske konsultationer.
Udbredte læsioner med erytem og pustler opstår pludseligt.
relevance score : -100.0%
ReferencesAcute generalized exanthematous pustulosis (AGEP) er en hudreaktion præget af små, pusfyldte knopper på en rød hudbase. Det sker normalt, når nogen tager visse medikamenter, såsom antibiotika, og spreder sig hurtigt over hele kroppen. Efter at den udløsende medicin er stoppet, forsvinder symptomerne typisk inden for to uger, ofte med efterladenskaber i form af hududskillelse. Selvom tilstanden normalt ikke er alvorlig og er begrænset til huden, kan alvorlige tilfælde klassificeres sammen med andre alvorlige hudreaktioner såsom Stevens-Johnson syndrome eller toxic epidermal necrolysis. Behandlingen er primært støttende, og prognosen for fuldstændig helbredelse er normalt fremragende.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
En 76-årig mand kom på skadestuen, fordi hans hud havde ændret sig de seneste to dage. Læger fandt røde pletter og hævede områder på hans bagagerum og arme og ben. Som tiden gik, slog disse pletter sig sammen, og han udviklede bumslignende knopper i de røde områder. Tests viste højt antal hvide blodlegemer med masser af en type kaldet neutrofiler og øgede niveauer af C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
