Erythema nodosum
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Det fremstår som en smertefuld erytematøs knude på benet.
References
Erythema nodosum er den mest almindelige type panniculitis, karakteriseret ved smertefulde røde knuder, hovedsageligt fundet på underbenene. Dens nøjagtige årsag er stadig ukendt, men det ser ud til at skyldes en overdreven reaktion på forskellige udløsere. Selvom dets oprindelse ofte er usikker, er det vigtigt at udelukke andre underliggende tilstande før diagnosticering primary erythema nodosum. Det kan indikere begyndelsen af systemiske sygdomme som infektioner, betændelse, kræft eller reaktioner på medicin. Almindelige udløsere inkluderer strep infections, tuberculosis, sarcoidosis, Behçet's disease, inflammatory bowel disease, certain medications, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis henviser til en række forskellige inflammatoriske tilstande, der påvirker fedtvævet under huden. Disse tilstande er ualmindelige hos børn. Panniculitis kan enten være hovedproblemet i en systemisk tilstand eller en reaktion sekundær til faktorer som infektion, skade eller visse medikamenter. Uanset årsagen viser de fleste typer panniculitis lignende symptomer, herunder smertefulde, røde knuder under huden.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , en betændelse i fedtlaget under huden, er en sjælden tilstand, der normalt viser sig som hævede knuder eller pletter. Erythema nodosum (EN) er den mest almindelige type, ofte udløst af forskellige faktorer. Mens omkring 55% af tilfældene ikke har nogen klar årsag, omfatter almindelige triggere infektioner, medicin, visse sygdomme som sarkoidose og inflammatorisk tarmsygdom, graviditet og kræft. EN optræder normalt hos teenagere og unge voksne, oftere hos kvinder. Det er ofte forudgået af en generel følelse af sygdom, der varer en til tre uger, med symptomer som feber og øvre luftvejsproblemer. Derefter vises røde knuder, normalt på ydersiden af arme og ben, hvilket forårsager smerte. EN's nøjagtige årsag er ikke fuldt ud forstået, men det menes at involvere immunkomplekser i små blodkar i fedtlaget, hvilket fører til betændelse. Typisk viser en biopsi betændelse i fedtlaget uden skader på blodkar. Selv uden specifik behandling for den underliggende årsag, løser EN ofte af sig selv. Så de fleste patienter har kun brug for støttende behandling for deres symptomer.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Panniculitis, an inflammation of the fat layer under the skin, is a rare condition usually showing up as swollen nodules or patches. Erythema nodosum (EN) is the most common type, often triggered by various factors. While around 55% of cases have no clear cause, common triggers include infections, medications, certain diseases like sarcoidosis and inflammatory bowel disease, pregnancy, and cancer. EN usually appears in teens and young adults, more often in females. It's often preceded by a general feeling of illness lasting one to three weeks, with symptoms like fever and upper respiratory issues. Then, red nodules appear, usually on the outer sides of arms and legs, causing pain. EN's exact cause isn't fully understood, but it's believed to involve immune complexes in small blood vessels of the fat layer, leading to inflammation. Typically, a biopsy shows inflammation in the fat layer without damage to blood vessels. Even without specific treatment for the underlying cause, EN often resolves on its own. So, most patients need only supportive care for their symptoms.
Erythema nodosum diagnosticeres klinisk. En biopsi kan tages og undersøges mikroskopisk for at bekræfte en usikker diagnose. Et røntgenbillede af thorax bør udføres for at udelukke lungesygdomme, især sarkoidose og tuberkulose.