Livedoid vasculitis - Livedoid Vaskulitis
Livedoid Vaskulitis (Livedoid vasculitis) er en kronisk hudsygdom, der primært forekommer hos unge til midaldrende kvinder. Et akronym, der bruges til at beskrive dens træk, er “Smertefulde purpuriske sår med retikulært mønster i underekstremiteterne” (PURPLE). Sygdommen er forbundet med en række tilstande, herunder kronisk venøs hypertension og åreknuder.
☆ AI Dermatology — Free Service
I 2022 Stiftung Warentest-resultaterne fra Tyskland var forbrugernes tilfredshed med ModelDerm kun lidt lavere end med betalte telemedicinske konsultationer.
I 2022 Stiftung Warentest-resultaterne fra Tyskland var forbrugernes tilfredshed med ModelDerm kun lidt lavere end med betalte telemedicinske konsultationer.
Det kan ledsages af smerte.
relevance score : -100.0%
ReferencesLivedoid vasculopathy er en sjælden hudlidelse, der er karakteriseret ved smertefulde sår, som gentagne gange opstår på underbenene.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy er en sjælden hudlidelse, der forårsager tilbagevendende sår på underbenene og efterlader blege ar, kendt som atrophie blanche. Mens den nøjagtige årsag stadig er uklar, menes det, at øget blodkoagulering (hypercoagulability) er hovedfaktoren, mens betændelse spiller en sekundær rolle. Faktorer, der bidrager til koaguleringen, omfatter følgende: deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin‑gene mutations og high levels of homocysteine. I biopsier viser tilstanden blodpropper inde i kar, fortykkelse af karvæggene og ardannelse. Behandling involverer en flerstrenget tilgang med fokus på forebyggelse af blodpropper ved brug af medicin såsom anti‑blodplademedicin, blodfortyndere og fibrinolytisk terapi. Forskellige lægemidler kan anvendes til denne hudtilstand, herunder colchicine og hydroxychloroquine, vasodilators og immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy er en sjælden tilstand, hvor der opstår læsioner på begge ben. Dannelsen af blodpropper i bittesmå blodkar menes at skyldes øget koagulation og nedsat nedbrydning af blodpropper samt skader på karens foring. Tilstanden forekommer hyppigere hos kvinder, især i alderen 15–50 år. Rygestop, korrekt sårpleje og brug af blodfortyndende samt blodpladehæmmende medicin har vist sig at være effektive.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
