Melasma
☆ I 2022 Stiftung Warentest-resultaterne fra Tyskland var forbrugernes tilfredshed med ModelDerm kun lidt lavere end med betalte telemedicinske konsultationer.
Det er en almindelig tilstand observeret hos asiatiske kvinder i deres tidlige 40'ere. Den cirklede læsion på billedet er tættere på lentigo i stedet for melasma.
References
Tranexamic acid is a novel treatment option for melasma; however, there is no consensus on its use. This systematic review searched major databases for relevant publications to March 2016. Eleven studies with 667 participants were included. Pooled data from tranexamic acid-only observational studies with pre- and post-treatment Melasma Area and Severity Index (MASI) showed a decrease of 1.60 in MASI after treat?ment with tranexamic acid. The addition of tranexamic acid to routine treatment modalities resulted in a further decrease in MASI of 0.94. These results support the efficacy and safety of tranexamic acid, either alone or as an adjuvant to routine treatment modalities for melasma.
For nylig er low-fluence Q-switched Nd:YAG (LFQSNY) laser blevet populær til behandling af melasma, især i Asien. At opsummere forskellige undersøgelser var udfordrende, men LFQSNY virker generelt effektiv og sikker for melasma sammenlignet med traditionelle terapier. Nogle tilfælde af plettet hypopigmentering er dog blevet rapporteret som en bivirkning af LFQSNY, muligvis på grund af høj laserenergi. Aggressiv brug af LFQSNY kan også føre til hyperpigmentering fra betændelse, især i mørkere hudtoner.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Recently, the low-fluence Q-switched Nd:YAG laser (LFQSNY) has been widely used for treating melasma, especially in Asia. It was hard to summarize the heterogenous studies, but LFQSNY appeared to be a generally effective and safe treatment for melasma considering the results of previous conventional therapies. However, mottled hypopigmentation has been occasionally reported to develop and persist as an adverse event of LFQSNY, which may be associated with the high accumulated laser energy. When used aggressively, even LFQSNY can induce hyperpigmentation via unwanted inflammation, especially in darker skin.
Pigmenteringsproblemer findes ofte i primærplejen. Almindelige typer hyperpigmenteringsforstyrrelser omfatter post-inflammatory hyperpigmentation, melasma, sunspots, freckles, and café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Pigmentation problems are often found in primary care. Common types of hyperpigmentation disorders include post-inflammatory hyperpigmentation, melasma, sunspots, freckles, café au lait spots.
Melasma kan ikke løses med laserbehandling i en vis periode, da det er en sygdom, hvor der kontinuerligt produceres pigment. Tranxenemisk syre hjælper med at forbedre for at reducere pigmenteringen.
○ Behandling
I nogle lande (f.eks. Japan, Korea) fås oral tranexamsyre i håndkøb og er effektiv. Melasmacremen med tranexamsyre og azelainsyre kan være delvist nyttig.
Hydroquinon kan bruges topisk til behandling af hyperpigmentering, men FDA stoppede OTC-produkterne indeholdende hydroquinon fra 2020.
#Tranexamic acid [TRANSINO]
#Laser toning technique (low fluence QS1064 laser)
#Triluma