Onychomycosis - Neglesvamp
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En tånegl påvirket af Neglesvamp (Onychomycosis)
En persons fod med en svampe-negleinfektion ti uger inde i et kursus med terbinafin oral medicin. Bemærk båndet med sund neglevækst bag de resterende inficerede negle.
relevance score : -100.0%
ReferencesSystemiske antimykotika er den mest effektive behandling. Metaanalyser viser mykotiske helbredelsesrater som følger: terbinafine = 76 %, itraconazole with pulse dosing = 63 %, itraconazole with continuous dosing = 59 %, fluconazole = 48 %. Samtidig øger debridering af neglene hærdningshastigheden yderligere. Topisk terapi med ciclopirox er mindre effektiv; den har en fejlprocent på over 60 %.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onychomycosis er en svampeinfektion, der påvirker neglene. Når den er forårsaget af dermatofytter, kaldes den tinea unguium. Onychomycosis omfatter infektioner forårsaget af dermatofytter, gær og skimmelsvamp. Et negleproblem, der ikke skyldes en svampeinfektion, kaldes en nail dystrophy. Selvom den kan påvirke både fingernegle og tånegle, er onychomycosis i tåneglene mere almindelig. Denne artikel diskuterer forskellige aspekter af toenail onychomycosis, såsom virkning, kliniske typer, stadier, diagnose og behandling. Selvom den ikke er livstruende, kan onychomycosis føre til alvorlige komplikationer som cellulitis, sepsis, knogleinfektion, vævsskader og negletab.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine er en medicin, der bekæmper svampeinfektioner ved at blokere squalenepoxidase. Den er effektiv mod mange typer hudsvampe og er godkendt til behandling af neglesvamp, når den tages oralt. De fleste bivirkninger, såsom hovedpine og maveproblemer, er milde og forsvinder af sig selv. Ændringer i smag (dysgeusi) kan variere fra milde til svære og kan i sjældne tilfælde føre til vægttab. Permanente smagsændringer er sjældne, men er blevet rapporteret.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onychomycosis er en svampeinfektion, der påvirker neglene. Omkring 90 % af tånegleinfektionerne og 75 % af negleinfektionerne skyldes svampe (Trichophyton mentagrophytes, Trichophyton rubrum). Symptomerne omfatter misfarvning af neglene, fortykkelse, adskillelse fra neglebunden og overvækst. Behandlingen involverer typisk oral medicin såsom terbinafine(terbinafin) eller itraconazole(itraconazol), mens topiske behandlinger kan anvendes ved milde til moderate tilfælde.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Den svampedræbende medicin terbinafine, som tages oral, anses for at være den mest effektive, men terbinafine er forbundet med leverbivirkninger.
Neglesvamp (onychomycosis) forekommer hos omkring 10 % af den voksne befolkning, og ældre mennesker er hyppigere ramt. Mænd rammes oftere end kvinder. Neglesvamp (onychomycosis) udgør omkring halvdelen af alle neglesygdomme. Det betyder, at deformitet af tåneglene også kan skyldes andre årsager end onychomycosis.
○ Behandling – håndkøbsmedicin
Det er svært at behandle onychomycosis med topisk medicin, fordi lægemidler har svært ved at trænge ind i de fortykkede tånegle.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Behandling
Langtidsbehandling er normalt påkrævet, indtil den inficerede tånegl er helt fjernet.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer