Prurigo nodularis
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References
Prurigo nodularis er en langvarig hudlidelse karakteriseret ved flere faste knopper og knuder, som normalt findes på de ydre dele af arme og ben. Disse knopper kan variere i farve fra kød-tonet til pink og er intenst kløende. De kan påvirke mennesker i alle aldre og er ofte forbundet med andre hudsygdomme, der forårsager kronisk kløe, såsom atopisk dermatitis. Behandlingsmuligheder omfatter stærk anti-kløe medicin, medicin, der påvirker immunsystemet, og medicin, der retter sig mod nervesystemet. Håndtering af prurigo nodularis involverer normalt langtidsbehandling.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Behandling involverer normalt brug af cremer eller injektioner af steroider på det berørte område. I mere alvorlige eller genstridige tilfælde kan det være nødvendigt med behandlinger som lysterapi eller medicin, der undertrykker immunsystemet. Thalidomid og lenalidomid er muligheder for alvorlige tilfælde, men de kan have alvorlige bivirkninger. Nyere behandlinger (opioid receptor antagonists, neurokinin-1 receptor antagonists) viser lovende behandling af prurigo nodularis med færre bivirkninger sammenlignet med thalidomid eller lenalidomid.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo er en hudlidelse karakteriseret ved langvarig kløe (varende over 6 uger) , ridserelaterede hudlæsioner og en historie med hyppige kradser. Det involverer neuroinflammation og fibrose i huden.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis er et langvarigt hudproblem præget af kløende knuder. Vi ved ikke præcis, hvad der forårsager det, men det ser ud til, at immun- og nerveproblemer spiller en rolle i kløe-ridse-cyklussen. Lige nu er der ingen behandlinger godkendt af US FDA specifikt til prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Behandling ― OTC-lægemidler
Vask af læsionsområdet med sæbe hjælper slet ikke og kan gøre det værre. OTC-steroidsalver kan hjælpe med at lindre symptomerne, men de skal normalt påføres i flere uger for at blive bedre. At fortsætte med at tage antihistaminer hjælper også med at lindre kløen.
#OTC steroid ointment
#OTC antihistamine
○ Behandling
#Intralesional triamcinolone injection