Syphilis - Syfilis
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Chancres ― primær syfilitisk infektion med Treponema pallidum
References
Syfilis er en seksuelt overført sygdom forårsaget af bakterien Treponema pallidum. I denne undersøgelse fokuserer vi på 57 patienter i alderen 18-68 år med sekundær syfilis.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Syfilis er en bakteriel infektion forårsaget af Treponema pallidum. Den kan efterligne forskellige sygdomme og give den kaldenavnet great imitator. Syfilis påvirker stadig millioner globalt, men kan behandles effektivt med penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum forårsager syfilis gennem seksuel kontakt eller fra mor til baby under graviditeten. Selvom der er simple tests til at diagnosticere det, og behandling med ét langtidsvirkende penicillinsprøjte virker godt, er syfilis ved at blive et stort problem igen på verdensplan. Dette gælder især blandt mænd, der har sex med mænd (MSM) i lande med høj og middel indkomst. Mens nogle lavindkomstlande har opfyldt WHO's mål for at stoppe syfilisoverførsel fra mor til baby, er der en bekymrende stigning i syfilis blandt HIV-positive MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Forstørret lever: Dette findes ofte og kan ske sammen med en forstørret milt. Undersøgelse af en leverbiopsi under mørkefeltsmikroskopi kan afsløre tilstedeværelsen af spiroketten. Leverfunktionsprøver kan vise abnormiteter. (2) Gulfarvning af huden (gulsot) : Hvorvidt nogen viser gulsot afhænger af, hvor meget leveren er påvirket. (3) Løbende næse: Ofte et af de første tegn, normalt inden for den første uge efter fødslen. (4) Hævede lymfeknuder: Generaliseret hævelse af lymfeknuder, normalt smertefri, er også almindelig. (5) Hududslæt: Et udslæt opstår typisk en til to uger efter den løbende næse. Du kan måske se små røde eller lyserøde pletter på ryggen, balderne, lårene og fodsålerne. Dette udslæt kan udvikle sig til afskalning og skorpedannelse.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnose og behandling
VDRL og RPR kan bruges til at bekræfte nylig infektion og screene for syfilis. FTA-ABS test er en mere specifik test og kan bruges til at tjekke for tidligere infektionshistorie. Penicillin bruges til at behandle syfilis.