Vitiligo
☆ I 2022 Stiftung Warentest-resultaterne fra Tyskland var forbrugernes tilfredshed med ModelDerm kun lidt lavere end med betalte telemedicinske konsultationer.
Vitiligo af fingrene er sværere at behandle end andre områder. Bortset fra at være kosmetisk uskøn, er vitiligo normalt og ikke smitsomt. Inden for dermatologi er den mest effektive behandling fototerapi eller laserbehandling (excimer) 2-3 gange om ugen i mindst 1 år. Hvis du ikke kan komme ofte på hospitalet af økonomiske årsager eller fordi du har travlt, kan du prøve en fototerapimaskine, der er godkendt til hjemmebrug.
Øjenlågsvitiligo
Vitiligo på hånden
References
Vitiligo er en almindelig hudsygdom, der forårsager pletter af hvid hud på grund af tab af melanocytter. Nyere forskning viser, at det er en autoimmun sygdom. Selvom det ofte ses som et kosmetisk problem, kan det dybt påvirke mentalt velvære og hverdagsliv. I 2011 klassificerede eksperter en type kaldet segmental vitiligo adskilt fra andre.
Vitiligo is a common skin disorder that causes patches of white skin due to the loss of melanocytes. Recent research shows it's an autoimmune disease. While it's often seen as a cosmetic issue, it can deeply affect mental well-being and daily life. In 2011, experts classified a type called segmental vitiligo separately from others.
Vitiligo is a common skin disorder that causes patches of white skin due to the loss of melanocytes. Recent research shows it's an autoimmune disease. While it's often seen as a cosmetic issue, it can deeply affect mental well-being and daily life. In 2011, experts classified a type called segmental vitiligo separately from others.
Patienter med aktiv vitiligo har flere behandlingsmuligheder, såsom systemiske glukokortikoider, fototerapi og systemiske immunsuppressiva. Stabile vitiligopatienter kan finde lindring fra topiske kortikosteroider, topiske calcineurinhæmmere, fototerapi og transplantationsprocedurer. Nylige fremskridt i forståelsen af vitiligos underliggende processer har ført til udviklingen af målrettede terapier. I øjeblikket er JAK-hæmmere de mest lovende og tilbyder god tolerabilitet og funktionelle resultater, på trods af risikoen for at aktivere latente infektioner og systemiske bivirkninger, der er almindelige med andre immunsuppressive midler. Igangværende forskning har til formål at identificere nøglecytokiner involveret i vitiligos udvikling (IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, TNF) . Blokering af disse cytokiner har vist lovende i dyremodeller og nogle patienter. Derudover er undersøgelser af miRNA-based therapeutics og adoptive Treg cell therapy i gang.
Current models of treatment for vitiligo are often nonspecific and general. Various therapy options are available for active vitiligo patients, including systemic glucocorticoids, phototherapy, and systemic immunosuppressants. While stable vitiligo patients may benefit from topical corticosteroids, topical calcineurin inhibitors, phototherapy, as well as transplantation procedures. Recently, a better understanding of the pathophysiological processes of vitiligo led to the advent of novel targeted therapies. To date, JAK inhibitors are the only category that has been proved to have a good tolerability profile and functional outcomes in vitiligo treatment, even though the risk of activation of latent infection and systemic side effects still existed, like other immunosuppressive agents. Research is in progress to investigate the important cytokines involved in the pathogenesis of vitiligo, including IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, and TNF, the blockade of which has undergone preliminary attempts in animal models and some patients. In addition, studies on miRNA-based therapeutics as well as adoptive Treg cell therapy are still primary, and more studies are necessary.
Current models of treatment for vitiligo are often nonspecific and general. Various therapy options are available for active vitiligo patients, including systemic glucocorticoids, phototherapy, and systemic immunosuppressants. While stable vitiligo patients may benefit from topical corticosteroids, topical calcineurin inhibitors, phototherapy, as well as transplantation procedures. Recently, a better understanding of the pathophysiological processes of vitiligo led to the advent of novel targeted therapies. To date, JAK inhibitors are the only category that has been proved to have a good tolerability profile and functional outcomes in vitiligo treatment, even though the risk of activation of latent infection and systemic side effects still existed, like other immunosuppressive agents. Research is in progress to investigate the important cytokines involved in the pathogenesis of vitiligo, including IFN-γ, CXCL10, CXCR3, HSP70i, IL-15, IL-17/23, and TNF, the blockade of which has undergone preliminary attempts in animal models and some patients. In addition, studies on miRNA-based therapeutics as well as adoptive Treg cell therapy are still primary, and more studies are necessary.
Der er ingen kendt kur mod vitiligo. For dem med lys hud er solcreme og makeup alt, der typisk anbefales. Andre behandlingsmuligheder kan omfatte steroidcremer eller fototerapi.
○ Behandling
#Phototherapy
#Excimer laser
#Tacrolimus ointment