Hand eczemahttps://en.wikipedia.org/wiki/Hand_eczema
Hand eczema presents on the palms and soles, and may sometimes be difficult or impossible to differentiate from atopic dermatitis, allergic contact dermatitis, and psoriasis, which also commonly involve the hands. 

Normally, skin inflammation connected with hand eczema is accompanied by blister formation and pronounced itching, but solid calluses and painful tearing may also occur.

A single cause is not seldom for the development of hand eczema in patients.: environmental factors such as excessive hand washing; contact with allergens or irritants; and genetic disposition.

Hand eczema is a common disease: study data indicates a one-year prevalence of up to 10% in the general population.

○ Treatment ― OTC Drugs
Do not use soap or hand sanitizer. Due to the thick skin on the palms and soles, low-potency OTC steroid ointments may not work. In this case, a doctor's prescription is required to use a strong steroid ointment.
#Hydrocortisone ointment

If symptoms are severe, taking an OTC antihistamine daily can also help.
#Cetirizine [Zytec]
#Diphenhydramine [Benadryl]
#LevoCetirizine [Xyzal]
#Fexofenadine [Allegra]
#Loratadine [Claritin]

Apply an OTC antibiotic if the cracked lesion is painful.
#Bacitracin
  • Reducing the use of soaps and cleaners is important for treatment.
  • Mild form of hand eczema
  • Hand eczema hyperkeratosis ― When the symptoms become chronic and worsen, it may crack and bleed.
  • Eczema on the fingers
  • Severe case
References Hand eczema: an update 22960812
Hand eczema, one of the most common skin conditions affecting the hands, is also the most common type of skin disease related to work. Typically, only severe cases are diagnosed in dermatology clinics, as patients seldom seek help for early hand dermatitis. Mild cases are usually identified during routine occupational screenings. Hand eczema can become a long-lasting condition, persisting even after avoiding contact with the substance that triggers it. Key risk factors for hand eczema include a personal or family history of atopy, exposure to wet conditions, and contact with allergens. Studies show a higher prevalence of hand eczema among women, especially younger women in their twenties, likely due to environmental factors.
 Hand eczema 24891648 
NIH
Hand eczema is often a chronic, multifactorial disease. It is usually related to occupational or routine household activities. Exact etiology of the disease is difficult to determine. It may become severe enough and disabling to many of patients in course of time. An estimated 2-10% of population is likely to develop hand eczema at some point of time during life. It appears to be the most common occupational skin disease, comprising 9-35% of all occupational diseases and up to 80% or more of all occupational contact dermatitis.