Herpes simplexhttps://en.wikipedia.org/wiki/Herpes_simplex
Herpes simplex is a viral infection caused by the herpes virus. Infections are categorized by the part of the body affected. Oral herpes is common and involves the face or mouth; it often produces small blisters in clusters, known as cold sores or fever blisters. Genital herpes, frequently referred to simply as herpes, may cause mild symptoms or form blisters that rupture, leaving small ulcers that usually heal within two to four weeks. Tingling sensations can occur before the blisters appear. The first outbreak is often more severe and may be accompanied by fever, muscle aches, swollen lymph nodes, and headaches. Other conditions caused by the herpes virus include herpetic whitlow (when the fingers are involved), ocular herpes, and neonatal herpes (when a newborn is affected).

There are two types of herpes simplex virus: type 1 (HSV‑1) and type 2 (HSV‑2). HSV‑1 more commonly causes infections around the mouth, whereas HSV‑2 more often leads to genital infections. Both are transmitted through direct contact with an infected person. Genital herpes is classified as a sexually transmitted infection and can be passed to an infant during childbirth. After the initial infection, the viruses travel along sensory nerves to the nerve‑cell bodies, where they remain for life. Triggers for recurrence include reduced immune function, stress, and exposure to sunlight.

In most cases, antiviral drugs are used only when symptoms are severe. Daily antiviral therapy may be prescribed for individuals with very frequent outbreaks. No vaccine is available for herpes simplex, and the shingles vaccine does not provide protection against it. Antiviral medications such as aciclovir or valaciclovir can lessen symptom severity.

Worldwide, 60 % to 95 % of adults are infected with either HSV‑1 or HSV‑2. HSV‑1 infection usually occurs in childhood. An estimated 536 million people worldwide (16 % of the population) were infected with HSV‑2 as of 2003, with higher rates among women and in developing countries. Most people with HSV‑2 are unaware of their infection.

○ Treatment ― OTC Drugs
Avoid any physical contact, such as kissing a child, while blisters are present, as contact can spread the infection. Rest and refrain from drinking alcohol.
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  • Herpes simplex on the lip.
  • Herpes simplex ― Herpes simplex infection in fingers is more common in young children than in adults.
  • If symptoms are severe, antiviral medication is most effective for relieving them.
  • If a lesion occurs around the mouth, angular cheilitis should be considered in the differential diagnosis. However, in this image, herpes is more likely because several small vesicles are present around the mouth.
  • Herpes gingiva ― Herpes infections can occur not only around the mouth, but also in intraoral, perinasal, and periocular areas.
  • Herpes genitalis in females.
  • Herpes on the buttocks tends to relapse when you are tired.
  • When an infection is widespread, intensive treatment may be required, as in herpes zoster.
References Herpes Simplex Type 1 29489260 
NIH
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
 Herpes Simplex Type 2 32119314 
NIH
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
 Prevention and Treatment of Neonatal Herpes Simplex Virus Infection 32044154 
NIH
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
 Herpes simplex virus infection in pregnancy 22566740 
NIH
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
 Clinical management of herpes simplex virus infections: past, present, and future 30443341 
NIH
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.