Herpes simplexhttps://en.wikipedia.org/wiki/Herpes_simplex
Herpes simplex is a viral infection (herpes virus). Infections are categorized based on the part of the body infected. Oral herpes is a common disease and involves the face or mouth. It may result in small blisters in groups often called cold sores or fever blisters. Genital herpes, often simply known as herpes, may have mild symptoms or form blisters that break open and result in small ulcers. These typically heal over two to four weeks. Tingling pains may occur before the blisters appear. The first episode is often more severe and may be associated with fever, muscle pains, swollen lymph nodes and headaches. Other disorders caused by herpes virus include: herpetic whitlow when it involves the fingers, herpes of the eye, and neonatal herpes when it affects a newborn.

There are two types of herpes simplex virus, type 1 (HSV-1) and type 2 (HSV-2). HSV-1 more commonly causes infections around the mouth while HSV-2 more commonly causes genital infections. They are transmitted by direct contact with the infected individual. Genital herpes is classified as a sexually transmitted infection. It may be spread to an infant during childbirth. After infection, the viruses are transported along sensory nerves to the nerve cell bodies, where they reside lifelong. Causes of recurrence may include: decreased immune function, stress, and sunlight exposure.

In most cases, antiviral drugs are taken only when symptoms are severe. Daily antiviral medication may be prescribed to someone who has very frequent infection. There is no available vaccine and the shingles vaccine does not prevent herpes simplex. Treatments with antiviral medication such as aciclovir or valaciclovir can lessen the severity of symptoms.

Worldwide rates of either HSV-1 or HSV-2 are between 60% and 95% in adults. HSV-1 is usually infected during childhood. An estimated 536 million people worldwide (16% of the population) were infected with HSV-2 as of 2003 with greater rates among women and those in the developing world. Most people with HSV-2 do not realize that they are infected.

Treatment ― OTC Drugs
Avoid any physical contact, such as kissing a child, while the blisters are present, as contact can spread the infection to other people. You should rest without drinking alcohol.
#Acyclovir cream
  • Herpes simplex on the lip.
  • Herpes simplex ― Herpes simplex infection in fingers is more common in young children than in adults.
  • If symptoms are severe, taking antiviral drugs is most helpful in alleviating symptoms.
  • If it occurs around the mouth, angular cheilitis should be differentiated. However, in this picture, it is more likely to be herpes as there are several small blisters around the mouth.
  • Herpes gingiva ― Herpes infections can occur not only around the mouth, but also in intraoral, perinasal, and periocular areas.
  • Herpes genitalis in females.
  • Herpes on the buttocks is characterized by relapses when tired.
  • In cases of widespread infection, intensive treatment may be required, as with herpes zoster.
References Herpes Simplex Type 1 29489260 
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
 Herpes Simplex Type 2 32119314 
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
 Prevention and Treatment of Neonatal Herpes Simplex Virus Infection 32044154 
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
 Herpes simplex virus infection in pregnancy 22566740 
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
 Clinical management of herpes simplex virus infections: past, present, and future 30443341 
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.