Neurofibroma is a benign nerve-sheath tumor in the peripheral nervous system. In 90% of cases, they are found as stand-alone tumors without any genetic disorders. However, the remainder are found in persons with neurofibromatosis type I (NF1), an autosomal-dominant genetically inherited disease. They can result in a range of symptoms from physical disfiguration and pain to cognitive disability.

Neurofibroma may be 2 to 20 mm in diameter, is soft, flaccid, and pinkish-white. A biopsy can be used for histopathology diagnosis.

Neurofibroma typically arise in the teenage years and are often after puberty. In people with Neurofibromatosis Type I, they tend to continue to increase in number and size throughout adulthood.

  • Neurofibroma of the patient with neurofibromatosis.
  • Neurofibromas tend to worsen with age. The lesions in this individual first appeared when he was a teenager.
  • Solitary neurofibroma ― A soft erythematous papule.
References Neurofibroma 30969529 
Neurofibromas are the most prevalent benign peripheral nerve sheath tumor. Often appearing as a soft, skin-colored papule or small subcutaneous nodule, they arise from endoneurium and the connective tissues of peripheral nerve sheaths.