Neurofibromatosis is a complex multi-system human disorder caused by the mutation of neurofibromin. Neurofibromatosis causes tumors along the nervous system which can grow anywhere on the body. Neurofibromatosis is one of the most common genetic disorders and an autosomal dominant disorder.

Common symptoms of neurofibromatosis include brownish-red spots in the colored part of the eye called Lisch nodules and neurofibromas. Scoliosis (curvature of the spine), learning disabilities, vision disorders, mental disabilities, multiple café au lait spots and epilepsy may be also accompanied.

There is no specific treatment as of yet.

  • Cafe au lait macule seen in Neurofibromatosis type 1 (NF-1)
  • Multiple Neurofibromas (Von Recklinghausen disease)
  • Neurofibroma
  • Multiple small neurofibromas.
  • NF-1 ― Elderly patient's back.
  • Typical manifestation of NF-1. A number of neurofibromas are observed with speckled pigmentation.
  • Patient with facial angiofibroma caused by tuberous sclerosis
References Neurofibromatosis 29083784 
Neurofibromatosis is a neurocutaneous disorder characterized by tumors in the nervous system and skin. Neurofibromatosis types 1 and 2 are the most common and are distinct entities. Neurofibromatosis type 1, or von Recklinghausen disease, is an autosomal dominant disease. Neurofibromatosis type 1 presents with neurofibromas, cafe-au-lait macules, freckling, and optic gliomas. It is a clinical diagnosis. Neurofibromatosis type 2 (NF2) is a disease characterized by bilateral vestibular schwannomas (VS) and meningiomas. It has an autosomal dominant inheritance pattern. Treatment for neurofibromatosis types 1 and 2 is clinical monitoring and medical intervention when appropriate.