Palmoplantar pustulosis
Palmoplantar pustulosis is a chronic recurrent pustular dermatosis (that is, a pustulosis or pustular psoriasis) localized on the palms and soles only, characterized histologically by intraepidermal pustules filled with neutrophils. The use of systemic retinoids alone and in combination with photochemotherapy to improve symptoms of palmoplantar pustulosis.

Oral acitretin is effective for this type of psoriasis.
  • In this case, pompholyx can also be suspected.
  • In the absence of pustules, hand eczema can also be considered as a differential diagnosis.
References Palmoplantar Psoriasis 28846363 
Palmoplantar psoriasis is a variant of psoriasis that characteristically affects the skin of the palms and soles. It features hyperkeratotic, pustular, or mixed morphologies.
 Tumor Necrosis Factor Inhibitors 29494032 
Tumor necrosis factor (TNF)-alpha inhibitors, including etanercept (E), infliximab (I), adalimumab (A), certolizumab pegol (C), and golimumab (G), are biologic agents which are FDA-approved to treat ankylosing spondylitis (E, I, A, C, and G), Crohn disease (I, A and C), hidradenitis suppurativa (A), juvenile idiopathic arthritis (A), plaque psoriasis (E, I and A), polyarticular juvenile idiopathic arthritis (E), psoriatic arthritis (E, I, A, C, and G), rheumatoid arthritis (E, I, A, C, and G), ulcerative colitis (I, A and G), and uveitis (A).