Pompholyx is a type of dermatitis that is characterized by itchy blisters on the palms of the hands and bottoms of the feet. Blisters are generally one to two millimeters in size and heal over three weeks. However, they often recur. Redness is not usually present. Repeated recurrence of the disease may result in fissures and skin thickening.

Allergens, physical or mental stress, frequent hand washing, or metals aggrevates the disease. Diagnosis is typically based on what it looks like and the symptoms. Other conditions that produce similar symptoms include pustular psoriasis and scabies.

Treatment is generally with steroid cream. High strength steroid creams may be required for the first week or two. Antihistamines may be used to help with the itch.

Treatment ― OTC Drugs
Do not use soap. Since the palms and soles have thick skin, low potency OTC steroid ointments may not be effective. Taking an OTC antihistamine can also help.
#OTC steroid ointment
#OTC antihistamine

#High potency steroid ointment
  • Dyshidrotic dermatitis ― A severe case on hands
  • It seems that the lesion has almost improved.
  • In the chronic stage, scaly patch can be observed.
  • Clear blisters accompanied by severe itching.
  • Palmar dyshidrosis ― Peeling stage
  • In severe cases, it can appear as blisters with severe itching.
References Dyshidrotic Eczema: A Common Cause of Palmar Dermatitis 33173645 
Dyshidrotic eczema (DE) or acute palmoplantar eczema is a common cause of hand dermatitis in adults. It accounts for 5-20% of the causes of DE. It is a vesiculobullous disorder of the hands and soles. It is an intraepidermal spongiosis of the thick epidermis in which accumulation of edema causes the formation of small, tense, clear, fluid-filled vesicles on the lateral aspects of the fingers that can become large and form bullae. The vesicles can have a deep-seated appearance, which is referred to as “tapioca pudding.” In severe cases, lesions can extend to the palmar area and affect the entire palmar aspect of the hand. The diagnosis is mostly clinical and suggested by a recurrent rash of acute onset with vesicles and bullae located in the fingers extending to the palmar surfaces of the hands.
 Vesico-bullous rash caused by pompholyx eczema 22665876 
A 31-year-old man presented to dermatology with a 4 day history of an intensely itchy, linear, vesicular rash affecting the palms of both hands, on the background of recent exposure to a patient with scabies. The patient had a history of childhood eczema and asthma but no exacerbations in adulthood. Examination and microscopy revealed a vesicular rash with an absence of any burrows, mites or eggs. A provisional diagnosis of pompholyx eczema was made and the patient was commenced on mild topical corticosteroids. The patient re-presented 5 days later with worsening symptoms and a severe vesico-bullous rash