Syphilishttps://en.wikipedia.org/wiki/Syphilis
Syphilis is a sexually transmitted infection caused by Treponema pallidum. The signs and symptoms of syphilis vary according to the stage in which the infection presents (primary, secondary, latent, and tertiary). ○ Primary stage: Typically presents with a single chancre (a firm, painless, non‑itchy skin ulceration usually 1–2 cm in diameter), although multiple sores can occur. ○ Secondary stage: A diffuse rash appears, often involving the palms of the hands and the soles of the feet. Sores may also develop in the mouth or vagina. ○ Latent stage: This stage can last for years and may produce few or no symptoms. ○ Tertiary stage: May involve gummas (soft, non‑cancerous growths), neurological complications, or cardiac manifestations. Syphilis can mimic the symptoms of many other diseases.

○ Diagnosis and Treatment
VDRL and RPR tests can confirm recent infection and serve as screening tools. The FTA‑ABS test is more specific and can detect prior infection. Penicillin is the treatment of choice for syphilis.

☆ In the 2022 Stiftung Warentest results from Germany, consumer satisfaction with ModelDerm was only slightly lower than with paid telemedicine consultations.
  • Chancres ― primary syphilitic infection by Treponema pallidum
  • Jarisch Herxheimer reaction ― Syphilis and human immunodeficiency virus
  • Secondary syphilis
References Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis 20502522 
NIH
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
 Syphilis 30521201 
NIH
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
 Syphilis 29022569 
NIH
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
 Congenital Syphilis 30725772 
NIH
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.