Livedoid vasculitis - Livedoida Vaskulito
Livedoida Vaskulito (Livedoid vasculitis) estas kronika haŭta malsano vidita ĉefe ĉe junaj ĝis mezaĝaj virinoj. Unu akronimo uzata por priskribi ĝiajn trajtojn estas "Doloraj purpuraj ulceroj kun retika ŝablono de malsuperaj ekstremaĵoj" (PURPURA). Ĝi estas rilata al kelkaj malsanoj, inkluzive de kronika vejna hipertensio kaj varikozecoj.
☆ En la 2022 Stiftung Warentest rezultoj de Germanio, konsumanto kontento kun ModelDerm estis nur iomete pli malalta ol kun pagitaj telemedicinaj konsultoj.
Ĝi povas esti akompanata de doloro.
References
Livedoid vasculopathy estas malofta haŭta kondiĉo karakterizita de doloraj ulceroj, kiuj daŭre revenas sur la malsuprajn krurojn.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy estas malofta haŭta kondiĉo, kiu kaŭzas ripetiĝantajn ulcerojn sur la malsupraj kruroj, postlasante palajn cikatrojn konatajn kiel atrofio blanka. Kvankam la preciza kaŭzo ankoraŭ estas neklara, oni kredas, ke pliigita sangokoagulado (hypercoagulability) estas la ĉefa faktoro, kun inflamo ludas sekundaran rolon. Faktoroj kontribuantaj al koaguliĝo inkluzivas jene - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. En biopsioj, la kondiĉo montras sangajn koagulaĵojn ene de angioj, dikiĝo de angiaj muroj kaj cikatriĝo. Traktado implikas multflankan aliron, kiu koncentriĝas pri preventado de sangokoagulaĵoj per medikamentoj kiel kontraŭplaketaj drogoj, sangaj diluantoj kaj fibrinoliza terapio. Diversaj drogoj povas esti uzataj por ĉi tiu haŭta kondiĉo - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy estas malofta kondiĉo kie lezoj okazas sur ambaŭ kruroj. La formado de sangaj koagulaĵoj en etaj sangaj glasoj supozeble estas kaŭzita de pliigita koaguliĝo kaj reduktita koaguliĝo, kune kun damaĝo al la angia tegaĵo. Ĝi estas pli ofta ĉe inoj, precipe inter aĝoj 15 kaj 50. Ĉesi fumi, prizorgi vundojn kaj uzi medikamentojn kiel sangaj diluantoj kaj kontraŭplakitaj drogoj estis efikaj.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
