Porokeratosis - Porokeratozo
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References
Porokeratosis estas malofta haŭta kondiĉo karakterizita de keratinigproblemoj, rezultigante levitajn, ringformajn makulojn aŭ malglatajn tuberojn sur la haŭto. Ĝia difina trajto sub la mikroskopo estas la ĉeesto de kornoida lamelo, specifa aranĝo de ĉeloj en la supra tavolo de la haŭto. Porokeratosis venas en diversaj formoj (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Gravas noti, ke porokeratosis eble povas evolui al haŭta kancero. La plej bona maniero por diagnozi porokeratosis estas per biopsio de la levita limo, kvankam nuntempe ne ekzistas norma traktado-protokolo.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) estas malsano de malorda keratiniĝo. Ĝi estas unu el ses specoj de porokeratozo, kaj ĝi tipe influas pli grandajn areojn kompare kun la aliaj (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . La erupcia tipo de porokeratozo ofte ligas al kancero, malfortigita imuneco aŭ inflamo. Riskfaktoroj implikas genetikon, imunsubpremadon kaj sunekspozicion. DSAP komenciĝas kiel rozkoloraj aŭ brunaj tuberoj kun plialtigitaj randoj en sun-senŝirmaj lokoj, foje kaŭzante iometan jukadon. Traktado varias kaj povas inkluzivi topikajn kremojn, malpezan terapion aŭ medikamentojn kiel 5-fluorouracilo aŭ retinoidoj. Ĉi tiuj lezoj estas konsiderataj antaŭkanceraj, kun 7. 5 - 10 % ŝanco iĝi skvamoĉela aŭ bazĉela karcinomo.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52-jara viro, antaŭe sana, envenis kun plata, ringforma makulo ĉe la fino de sia kvara piedfingro, kiu estis tie dum 2 jaroj sen kaŭzi ajnan simptomon. Ĝi komenciĝis kiel malgranda, malmola tubero kaj kreskis eksteren kun la tempo. Malgraŭ provado de diversaj traktadoj kiel krioterapio, kremoj, kontraŭfungaj kaj antibiotikoj, la peceto ne pliboniĝis. Atente ekzamenante ĝin per dermokopsio montris sekan, ruĝan centron kun dika, malglata bordo. Eta peco de haŭto prenita de la rando de la peceto montris eksternorman ĉelan kreskon en la ekstera tavolo de la haŭto, konfirmante diagnozon de porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ofte biopsio estas farita ĉar ĝi povas aspekti simila al aktina keratozo aŭ skvamoĉela karcinomo.