Porokeratosis - Porokeratozo
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La malmolaj, elstaraj randoj estas karakterizaj.
relevance score : -100.0%
ReferencesPorokeratosis estas malofta haŭta kondiĉo karakterizita de keratinigproblemoj, kiuj rezultas en levitaj, ringformaj makuloj aŭ malglataj tuberoj sur la haŭto. Ĝia difina trajto sub la mikroskopo estas la ĉeesto de kornoida lamelo, specifa aranĝo de ĉeloj en la supra tavolo de la haŭto. Porokeratosis aperas en diversaj formoj (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Gravas noti, ke porokeratosis eble povas evolui al haŭta kancero. La plej fidinda maniero por diagnozi porokeratosis estas per biopsio de la levita limo, kvankam nuntempe ne ekzistas normigita traktadprotokolo.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) estas malsano de malordigita keratinigo. Ĝi estas unu el ses specoj de porokeratozo, kaj ĝi tipe influas pli grandajn areojn ol la aliaj (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis). La erupcia tipo de porokeratozo ofte estas ligita al kancero, malfortigita imuno aŭ inflamo. Riskfaktoroj implikas genetikon, imunsubpremadon kaj sunekspozicion. DSAP komenciĝas kiel rozkoloraj aŭ brunaj tuberoj kun plialtigitaj randoj en sun‑senŝirmitaj lokoj, foje kaŭzante iomete jukadon. Traktado varias kaj povas inkluzivi topikajn kremojn, malpezan terapion aŭ medikamentojn kiel 5‑fluorouracil aŭ retinoids. Ĉi tiuj lezoj estas konsiderataj antaŭkanceraj, kun 7,5‑10 % ŝanco iĝi skvamoĉela aŭ bazĉela karcinomo.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52-jara viro, antaŭe sana, venis kun plata, ringforma makulo ĉe la fino de sia kvara piedfingro, kiu estis tie dum du jaroj sen kaŭzi ajnan simptomon. Ĝi komenciĝis kiel malgranda, malmola tubero kaj kun la tempo kreskis eksteren. Malgraŭ provado de diversaj traktadoj, kiel krioterapio, kremoj, kontraŭfungaj kaj antibiotikaj preparatoj, la makulo ne pliboniĝis. Atente ekzamenante ĝin per dermokopsio montris sekajn, ruĝan centron kun dika, malglata bordo. Eta peco de haŭto prenita de la rando de la makulo montris eksternorman ĉelan kreskon en la eksteraj tavoloj de la haŭto, konfirmante diagnozon de porokeratozo de Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Ofta biopsio estas farita, ĉar ĝi povas aspekti simila al aktina keratozo aŭ skvamoĉela karcinomo.