Panniculitis - Paniculitis
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La tuberculosis es una de las causas importantes.
References
Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.
Panniculitis forman un grupo heterogéneo de enfermedades inflamatorias que involucran el tejido adiposo subcutáneo. Estos trastornos son raros en los niños. La paniculitis puede ser el proceso primario de un trastorno sistémico o un proceso secundario que resulta de una infección, un trauma o la exposición a medicamentos. La mayoría de los tipos de paniculitis tienen la misma presentación clínica (independientemente de la etiología) , con nódulos subcutáneos eritematosos dolorosos.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.
Panniculitis , inflamación de la grasa subcutánea, suele presentarse con nódulos inflamatorios. Erythema nodosum (EN) es clínicamente la forma más frecuente de paniculitis. Si bien hasta el 55% de las NE se consideran idiopáticas, las causas más comunes incluyen infecciones, fármacos, enfermedades sistémicas como la sarcoidosis y la enfermedad inflamatoria intestinal, el embarazo y las neoplasias malignas. La EN suele presentarse en la adolescencia y en los años 20, y se observa con mayor frecuencia en mujeres. A menudo va precedido de un pródromo no específico de una a tres semanas, que puede incluir fiebre, malestar y síntomas de una infección del tracto respiratorio superior. Luego siguen lesiones cutáneas, típicamente localizadas en la cara extensora de las extremidades. Las lesiones son nódulos rojos no ulcerosos, dolorosos, redondeados u ovalados, ligeramente elevados. No se comprende la patogénesis exacta de la EN, aunque se cree que es el resultado del depósito de complejos inmunitarios en las vénulas de los septos de la grasa subcutánea, lo que causa una paniculitis neutrofílica. Incluso sin una terapia específica para la afección causante, la NE se resuelve sin tratamiento en la mayoría de los casos.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.
El "eritema nudoso" es una forma de paniculitis (panniculitis) caracterizada por nódulos rojos sensibles, de 1 a 10 cm, asociados con síntomas sistémicos que incluyen fiebre, malestar general y dolor articular. Los nódulos pueden desaparecer en un período de 2 a 6 semanas sin ulcerarse ni dejar cicatrices. El eritema nudoso se asocia con infecciones, como hepatitis C, EBV y tuberculosis, embarazo, linfoma no Hodgkin y cáncer de páncreas.