Porokeratosis - Poroqueratosis
☆ En los resultados de 2022 del Stiftung Warentest de Alemania, la satisfacción del consumidor con ModelDerm fue sólo ligeramente inferior que con las consultas de telemedicina pagadas.
Son característicos los bordes duros y salientes.
relevance score : -100.0%
ReferencesLa porokeratosis es una afección cutánea poco común que se caracteriza por alteraciones de la queratinización, lo que produce parches elevados en forma de anillo o protuberancias ásperas en la piel. Su rasgo definitorio al microscopio es la presencia de laminillas cornoides, una disposición específica de células en la capa córnea. La porokeratosis se presenta en varias formas, como disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum y linear porokeratosis. Es importante tener en cuenta que la porokeratosis puede transformarse en cáncer de piel. El método más fiable para diagnosticarla es la biopsia del borde elevado; sin embargo, actualmente no existe un protocolo de tratamiento estándar.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) es una enfermedad de queratinización alterada. Es uno de los seis tipos de porokeratosis y, por lo general, afecta áreas más extensas que los demás (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis). El tipo eruptivo de porokeratosis a menudo se asocia con cáncer, inmunosupresión o inflamación. Los factores de riesgo incluyen la predisposición genética, la inmunosupresión y la exposición solar. DSAP se presenta como protuberancias rosadas o marrones con bordes elevados en áreas expuestas al sol, que a veces provocan una ligera picazón. El tratamiento es variable e incluye cremas tópicas, fototerapia o fármacos como 5‑fluorouracilo y retinoides. Estas lesiones se consideran precancerosas, con una probabilidad del 7,5‑10 % de transformarse en carcinoma de células escamosas o de células basales.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Un hombre de 52 años, previamente sano, se presentó con un parche plano en forma de anillo en la punta del cuarto dedo del pie, que había permanecido allí durante 2 años sin causar síntomas. Apareció como un pequeño bulto duro y, con el tiempo, creció hacia afuera. A pesar de haber recibido varios tratamientos, como crioterapia, cremas, antimicóticos y antibióticos, el parche no mejoró. Al examinarlo de cerca con dermatoscopia, se observó un centro rojo y seco con un borde grueso y áspero. Una pequeña muestra de piel tomada del borde del parche reveló un crecimiento celular anormal en la capa externa de la piel, lo que confirma el diagnóstico de porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Con frecuencia se realiza una biopsia, ya que puede confundirse con la queratosis actínica o con el carcinoma de células escamosas.