Acne - Vinnid
☆ Saksamaa 2022. aasta Stiftung Warentesti tulemustes oli tarbijate rahulolu ModelDermiga vaid veidi madalam kui tasuliste telemeditsiini konsultatsioonidega.
Akne torso piirkonnas. Torso ülemine osa ja selg on tavalised akne piirkonnad.
References
Akne, kõige levinum nahahaigus Ameerika Ühendriikides, on püsiv põletikuline nahaprobleem. Ravi eesmärk on tegeleda nelja peamise aknet soodustava teguriga: liigne rasu tootmine, naharakkude kogunemine, Propionibacterium acnese kolonisatsioon ja sellest tulenev põletik. Toopilised retinoidid juhivad tõhusalt nii põletikulisi kui ka mittepõletikulisi kahjustusi, ennetades ja vähendades komedoone, vähendades samal ajal põletikku. Bensoüülperoksiid, mis on saadaval käsimüügis, on bakteritsiidne aine, mis ei soodusta bakterite resistentsust. Kuigi paiksed ja suukaudsed antibiootikumid toimivad üksi, suurendab nende efektiivsust nende kombineerimine paiksete retinoididega. Bensoüülperoksiidi lisamine antibiootikumravile vähendab bakterite resistentsuse riski. Suukaudset isotretinoiini, mis on heaks kiidetud raske ja kangekaelse akne korral, manustatakse iPLEDGE programmi kaudu.
Acne, the most common skin condition in the United States, is a persistent inflammatory skin problem. Treatment aims at addressing four main factors contributing to acne: excessive sebum production, skin cell buildup, Propionibacterium acnes colonization, and resulting inflammation. Topical retinoids effectively manage both inflammatory and non-inflammatory lesions by preventing and reducing comedones while addressing inflammation. Benzoyl peroxide, available over-the-counter, is a bactericidal agent without promoting bacterial resistance. While topical and oral antibiotics work alone, combining them with topical retinoids enhances their effectiveness. Adding benzoyl peroxide to antibiotic therapy lowers the risk of bacterial resistance. Oral isotretinoin, approved for severe and stubborn acne, is administered through the iPLEDGE program.
Acne, the most common skin condition in the United States, is a persistent inflammatory skin problem. Treatment aims at addressing four main factors contributing to acne: excessive sebum production, skin cell buildup, Propionibacterium acnes colonization, and resulting inflammation. Topical retinoids effectively manage both inflammatory and non-inflammatory lesions by preventing and reducing comedones while addressing inflammation. Benzoyl peroxide, available over-the-counter, is a bactericidal agent without promoting bacterial resistance. While topical and oral antibiotics work alone, combining them with topical retinoids enhances their effectiveness. Adding benzoyl peroxide to antibiotic therapy lowers the risk of bacterial resistance. Oral isotretinoin, approved for severe and stubborn acne, is administered through the iPLEDGE program.
Levinud akne paiksed ravimeetodid on benzoyl peroxide (BP) , salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, and sulfone agents. Suukaudsed antibiootikumid on pikka aega olnud akne ravi võtmeosa, eriti mõõdukate kuni raskete juhtumite korral. Need toimivad kõige paremini, kui neid kasutatakse koos paikse retinoidi ja BP-ga. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX) , trimethoprim, erythromycin, azithromycin, amoxicillin, and cephalexin on kõik näidanud tõhusust.
Common topical treatments for acne include benzoyl peroxide (BP), salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, sulfone agents. Oral antibiotics have long been a key part of acne treatment, especially for moderate to severe cases. They work best when used alongside a topical retinoid and BP. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX), trimethoprim, erythromycin, azithromycin, amoxicillin, cephalexin have all shown evidence of effectiveness.
Common topical treatments for acne include benzoyl peroxide (BP), salicylic acid, antibiotics, combinations of antibiotics with BP, retinoids, combinations of retinoids with BP or antibiotics, azelaic acid, sulfone agents. Oral antibiotics have long been a key part of acne treatment, especially for moderate to severe cases. They work best when used alongside a topical retinoid and BP. Tetracycline, doxycycline, minocycline, trimethoprim/sulfamethoxazole (TMP/SMX), trimethoprim, erythromycin, azithromycin, amoxicillin, cephalexin have all shown evidence of effectiveness.
Akne raviks on alati soovitatav kasutada paikseid retinoide. Süsteemsete või paiksete antibiootikumide kasutamisel on oluline kombineerida neid bensoüülperoksiidi ja retinoididega, kuid ainult kuni 12 nädala jooksul. Isotretinoin on ette nähtud raskete akne juhtude jaoks, mis ei ole reageerinud muudele ravimeetoditele. Kuigi füüsikaliste ravimeetodite, nagu laserteraapia ja keemilised koorimised, ning täiendavate lähenemisviiside (nt puhastatud mesilasmürk ja teatud dieedid) kohta on tõendeid, on nende tõhusus endiselt ebakindel.
Topical retinoids are always recommended for treating acne. When using systemic or topical antibiotics, it's important to combine them with benzoyl peroxide and retinoids, but only for up to 12 weeks. Isotretinoin is reserved for severe cases of acne that haven't responded to other treatments. While there's some evidence for physical treatments like laser therapy and chemical peels, as well as complementary approaches such as purified bee venom and certain diets, their effectiveness is still uncertain.
Topical retinoids are always recommended for treating acne. When using systemic or topical antibiotics, it's important to combine them with benzoyl peroxide and retinoids, but only for up to 12 weeks. Isotretinoin is reserved for severe cases of acne that haven't responded to other treatments. While there's some evidence for physical treatments like laser therapy and chemical peels, as well as complementary approaches such as purified bee venom and certain diets, their effectiveness is still uncertain.
Mitmed uuringud on uurinud, kuidas erinevad toidud mõjutavad aknet patsientidel. Nad leidsid, et aknega inimestel, kes söövad madala glükeemilise koormusega toite, on tavaliselt vähem aknelaike kui neil, kes söövad kõrge glükeemilise koormusega toite. Piimatooteid on uuritud ka seoses aknega. Näib, et teatud piimavalgud võivad aknet rohkem soodustada kui rasv või üldine piimasisaldus. Teised uuringud on keskendunud oomega-3 rasvhapetele ja y-linoolhappele. See viitab sellele, et akne põdevatel inimestel võib olla kasulik süüa rohkem kala ja tervislikke õlisid, et suurendada nende rasvhapete tarbimist. Hiljutised uuringud akne probiootikumide kohta näitavad paljutõotavaid tulemusi, kuid nende varajaste leidude kinnitamiseks on vaja rohkem uuringuid.
Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets. Dairy has also been a focus of study regarding dietary influences on acne; whey proteins responsible for the insulinotropic effects of milk may contribute more to acne development than the actual fat or dairy content. Other studies have examined the effects of omega-3 fatty acid and γ-linoleic acid consumption in individuals with acne, showing individuals with acne benefit from diets consisting of fish and healthy oils, thereby increasing omega-3 and omega-6 fatty acid intake. Recent research into the effects of probiotic administration in individuals with acne present promising results; further study of the effects of probiotics on acne is needed to support the findings of these early studies.
Several studies have evaluated the significance of the glycemic index of various foods and glycemic load in patients with acne, demonstrating individuals with acne who consume diets with a low glycemic load have reduced acne lesions compared with individuals on high glycemic load diets. Dairy has also been a focus of study regarding dietary influences on acne; whey proteins responsible for the insulinotropic effects of milk may contribute more to acne development than the actual fat or dairy content. Other studies have examined the effects of omega-3 fatty acid and γ-linoleic acid consumption in individuals with acne, showing individuals with acne benefit from diets consisting of fish and healthy oils, thereby increasing omega-3 and omega-6 fatty acid intake. Recent research into the effects of probiotic administration in individuals with acne present promising results; further study of the effects of probiotics on acne is needed to support the findings of these early studies.
Mõlema soo puhul näivad hormoonid, mida nimetatakse androgeenideks, olevat osa alusmehhanismist, põhjustades rasuerituse suurenemist. Teine levinud tegur on nahal leiduva bakteri Cutibacterium acnes liigne kasv.
Tavaliselt kasutatakse ravimeetodeid, mida rakendatakse otse kahjustatud nahale, nagu aselaiinhape, bensoüülperoksiid ja salitsüülhape. Antibiootikumid ja retinoidid on saadaval preparaatidena, mida kantakse nahale ja võetakse akne raviks suu kaudu. Antibiootikumravi tulemusena võib aga tekkida resistentsus antibiootikumide suhtes. Mitut tüüpi rasestumisvastased tabletid võivad aidata naistel aknet ära hoida. Akne varajane ja agressiivne ravi isotretinoiiniga võib aidata inimestel vähendada pikaajalisi tüsistusi.
○ Ravi
Adapalene geeli saab laialdaselt kasutada, kuna see pärsib rasueritust ja pärsib akne kordumist. Adapalene geel võib nahka ärritada, kui alguses seda liiga palju manustada. Bensoüülperoksiidi ja aselaiinhapet seevastu võib kasutada põletikuliste aknekohtade puhul, sest need aitavad põletikku vastu. Üldjuhul on efekti saavutamiseks vajalik pikaajaline ravi 1 kuu või kauem.
#Benzoyl peroxide [OXY-10]
#Adapalene gel [Differin]
#Tretinoin cream
#Minocycline
#Isotretinoin
#Topical clindamycin
#Comedone extraction