Acute generalized exanthematous pustulosis - Äge Generaliseerunud Eksantematoosne Pustuloos
Äge Generaliseerunud Eksantematoosne Pustuloos (Acute generalized exanthematous pustulosis) (AGEP) on haruldane nahareaktsioon, mis 90% juhtudest on seotud ravimite manustamisega. äge generaliseerunud eksantematoosne pustuloos (acute generalized exanthematous pustulosis) iseloomustab äkilisi nahalööbeid, mis ilmnevad keskmiselt viis päeva pärast ravi alustamist. Need lööbed on pustulid, st väikesed punased valged või punased nahalööbed, mis sisaldavad hägust või mädast materjali (mäda). Nahakahjustused taanduvad tavaliselt 1–3 päeva jooksul pärast rikkuva ravimi kasutamise lõpetamist.
☆ Saksamaa 2022. aasta Stiftung Warentesti tulemustes oli tarbijate rahulolu ModelDermiga vaid veidi madalam kui tasuliste telemeditsiini konsultatsioonidega.
Laialt levinud kahjustused koos erüteemi ja pustulitega tekivad äkki.
References
Acute generalized exanthematous pustulosis (AGEP) on nahareaktsioon, mida iseloomustavad väikesed mäda täis punnid punasel nahaalusel. Tavaliselt juhtub see siis, kui keegi võtab teatud ravimeid, näiteks antibiootikume, ja levib kiiresti üle keha. Pärast vallandava ravimi kasutamise lõpetamist kaovad sümptomid tavaliselt kahe nädala jooksul, jättes sageli nahale eraldumise. Kuigi tavaliselt ei ole need tõsised ja piirduvad nahaga, võib raskeid juhtumeid klassifitseerida koos muude tõsiste nahareaktsioonidega, nagu Stevens-Johnson syndrome või toxic epidermal necrolysis. Ravi on peamiselt toetav ravi ja haiguse täieliku lahenemise prognoos on tavaliselt suurepärane.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
76-aastane mees tuli kiirabisse, kuna tema nahk oli viimase kahe päeva jooksul muutunud. Arstid leidsid tema kehatüvelt ning kätelt ja jalgadelt punaseid laike ja kõrgenenud kohti. Aja möödudes need laigud ühinesid ja tal tekkisid punastesse piirkondadesse vistrikutaolised punnid. Testid näitasid kõrget valgevereliblede arvu koos paljude neutrofiilide tüüpidega ja suurenenud C-reactive protein taset.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
