Intraepithelial carcinoma (Bowen disease) - Intraepiteliaalne Kartsinoom (Boweni Tõbi)
☆ Saksamaa 2022. aasta Stiftung Warentesti tulemustes oli tarbijate rahulolu ModelDermiga vaid veidi madalam kui tasuliste telemeditsiini konsultatsioonidega.
Tüüpiline juhtum ― Intraepiteliaalne Kartsinoom (Boweni Tõbi) (Intraepithelial carcinoma (Bowen disease)) võidakse valesti diagnoosida kui kauakestvat, mittesügelevat ekseemi.
References
Bowen's disease (BD) on nahavähi tüüp, mis saab alguse naha välimisest kihist (epidermisest) . See on tavalisem kaukaaslastel ja esineb sageli päikesevalguse käes, kuid see võib ilmneda ka mujal. BD ilmneb tavaliselt ühe kahjustusena. BD-d peetakse sageli hoiatusmärgiks enne tõsisemat tüüpi nahavähi tekkimist. BD diagnoosimiseks tuginevad arstid tavaliselt koeproovide uurimisele mikroskoobi all (biopsia) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease mõjutab enamasti üle 60-aastaseid valgenahalisi inimesi. Peamised riskitegurid on pikaajaline päikese käes viibimine, nõrgenenud immuunsüsteem, kokkupuude arseeniga ja naha HPV-nakkus. HPV tüved 16, 18, 34 ja 48 on seotud Boweni tõvega suguelundite piirkonnas. HPV osalus mittesuguelunditel on vähem selge.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Tavaliselt ilmneb see erütematoosse, ketendava või koorikulise alana kõikjal kehal. Kõige tavalisem asukoht on sääred.
Seda saab ravida erinevate ravivõimalustega, nagu krüoteraapia, küretaaž, kauterdamine, fotodünaamiline ravi või kahjustuse ekstsisioon.
○ Diagnostika ja ravi
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy