Prurigo nodularis
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References
Prurigo nodularis on kauakestev nahahaigus, mida iseloomustavad mitmed kindlad punnid ja sõlmekesed, mis tavaliselt esinevad käte ja jalgade välistel osadel. Nende punnide värvus võib varieeruda lihatoonist roosani ja on intensiivselt sügelevad. Need võivad mõjutada igas vanuses inimesi ja on sageli seotud muude nahahaigustega, mis põhjustavad kroonilist sügelust, nagu atoopiline dermatiit. Ravivõimaluste hulka kuuluvad tugevad sügelusevastased ravimid, immuunsüsteemi mõjutavad ravimid ja närvisüsteemile suunatud ravimid. Prurigo nodularise ravi hõlmab tavaliselt pikaajalist ravi.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Prurigo nodularis is a chronic disorder of the skin that is classically seen as multiple, firm, flesh to pink colored papules, plaques and nodules commonly located on the extensor surfaces of the extremities. The lesions are very pruritic and can occur in any age group. It is commonly associated with another disease such as atopic dermatitis or any dermatoses associated with chronic pruritus. The therapeutic approach is wide-arrayed ranging from treatments that act as - potent antipruritics, immunomodulators, and neuromodulators. Treatment in an established case is prolonged and improving patient compliance with education and counseling is important.
Ravi hõlmab tavaliselt kreemide või steroidide süstimist kahjustatud piirkonda. Raskematel või kangekaelsematel juhtudel võib osutuda vajalikuks ravi nagu valgusteraapia või immuunsüsteemi pärssivad ravimid. Talidomiid ja lenalidomiid on valikuvõimalused rasketel juhtudel, kuid neil võib olla tõsiseid kõrvaltoimeid. Uuemad ravimeetodid (opioid receptor antagonists, neurokinin-1 receptor antagonists) näitavad paljutõotavat prurigo nodularis'e ravis vähemate kõrvaltoimetega võrreldes talidomiidi või lenalidomiidiga.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Treatment typically relies on the use of topical or intralesional steroids, though more severe or recalcitrant cases often necessitate the use of phototherapy or systemic immunosuppressives. Thalidomide and lenalidomide can both be used in severe cases; however, their toxicity profile makes them less favorable. Opioid receptor antagonists and neurokinin-1 receptor antagonists represent two novel families of therapeutic agents which may effectively treat PN with a lower toxicity profile than thalidomide or lenalidomide.
Chronic prurigo on nahahaigus, mida iseloomustab pikaajaline sügelus (kestab üle 6 nädala) , kriimustusega seotud nahakahjustused ja sagedased kriimustused. See hõlmab neuropõletikku ja fibroosi nahas.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Chronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching.
Prurigo nodularis on pikaajaline nahaprobleem, mida iseloomustavad sügelevad sõlmed. Me ei tea täpselt, mis seda põhjustab, kuid tundub, et immuun- ja närviprobleemid mängivad sügeluse-kriimustuse tsüklis oma rolli. Praegu ei ole USA FDA poolt spetsiaalselt prurigo nodularise jaoks heaks kiidetud ravimeid.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
Prurigo nodularis is a long-lasting skin problem marked by itchy nodules. We don't know exactly what causes it, but it seems that immune and nerve issues play a role in the itch-scratch cycle. Right now, there aren't any treatments approved by the US FDA specifically for prurigo nodularis.
○ Ravi ― OTC ravimid
Kahjustatud piirkonna pesemine seebiga ei aita sugugi ja võib seda hullemaks muuta. Börsivälised steroidsalvid võivad aidata sümptomeid leevendada, kuid tavaliselt tuleb neid paranemiseks kasutada mitu nädalat. Antihistamiinikumide võtmise jätkamine aitab samuti sügelust leevendada.
#OTC steroid ointment
#OTC antihistamine
○ Ravi
#Intralesional triamcinolone injection