Amyloidosis - Amiloidosia
☆ Alemaniako Stiftung Warentest-en 2022ko emaitzetan, ModelDerm-ekin kontsumitzaileen gogobetetasuna apur bat txikiagoa izan zen ordaindutako telemedikuntzako kontsultekin baino.
Amiloidosia (Amyloidosis)-ren aurpegiko ezaugarri klasikoak
References
26 urteko emakume bat gure klinikara etorri zen 10 urtez hanketan azkura erupzio bat zuelako kexatzen. Esteroide kremak eta tazaroteno krema erabili arren, erupzioa ez zen hobera egin. Ez zuen familiaren historia garrantzitsurik. Bera aztertu genuenean, hanken aurrealdean adabaki altxatuak eta latzak aurkitu genituen, lichen amyloidosis izeneko gaixotasunarekin bat zetozenak.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis larruazaleko gaixotasun arraroa da, kausa ezezaguneko azkura iraunkorrekin lotutakoa. Normalean larruazaleko kanpoko gainazaletan adabaki goratu eta koloreztatuen multzo gisa agertzen da. Lichen Amyloidosis 50 eta 60 urte bitarteko pertsonengan agertzen da normalean eta, zoritxarrez, ez dago sendabiderik. Orain eskuragarri dauden tratamenduek ez dute ondo funtzionatzen.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis iraupen luzeko larruazaleko azkura egoera bat da. Ezaguna da bizkarrean, izterretan, izterretan eta besoetan aurkitzen diren kolpe lodituen multzoengatik. Mikroskopioan aztertzen denean, Lichen amyloidosis azalaren goiko geruzan amiloide-pilaketa bat erakusten du, kanpoko azalaren loditzea eta handitzearekin batera. Lichen amyloidosis -ren kausa zehatza oraindik guztiz ulertzen ez den arren, aurreko ikerketek larruazaleko igurtzi edo marruskadurarekin, zelulen heriotzarekin, infekzio birikoekin, besteak beste, bezalako faktoreekin lotu dute. Lichen amyloidosis larruazaleko beste hainbat baldintzarekin lotuta dagoela dirudi, hala nola atopic dermatitis, lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnostikoa eta Tratamendua
#Electrophoresis of blood or urine
#Skin biopsy