Drug eruption
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Drug eruption gorputz osoan eragina izatearen ezaugarria da.
References
Botikak eragindako larruazaleko erreakzioak, botiken erupzioak izenez ezagutzen direnak, larriak izan daitezke batzuetan. Severe cutaneous adverse drug reactions (SCARs) izeneko erreakzio larri hauek bizitza arriskuan jartzen dira. Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) bezalako baldintzak biltzen dituzte. SCARs arraroak badira ere, ospitaleratutako pazienteen %2 inguruk jasaten dituzte.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
31 urteko emakume bat dermatologia sailera joan zen eskuineko oinaren goiko aldean minik gabeko adabaki gorri batekin. Doxiziklina dosi bat (100 mg) hartu zuen bezperan, aknearen orbainetarako picosegundoko laser tratamenduaren ondoren. Iaz, antzeko arazo bat bizi izan zuen leku berean, laser osteko doxiziklina dosi bera hartu ondoren. Ez du historia mediko esanguratsurik eta ez du beste sintomarik, sukarra bezalakorik, tokian bertan edo gorputz osoan.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Stevens-Johnson syndrome (SJS) eta toxic epidermal necrolysis (TEN) larruazaleko erreakzio larri baten bi forma dira, larruazaleko beste gaixotasun batzuetatik desberdinak, hala nola eritema multiforme handia eta estafilokokoko larruazaleko erreakzio estafilokokoa, baita botiken erreakzioekin ere. SJS/TEN erreakzio arraro eta larria da, larruazaleko eta mukos-mintzaren kalteak eragiten dituena, askotan sintoma sistemikoak dituena. Kasuen %80 baino gehiagotan, botikak dira kausa.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Droga-erupzioak, batez ere, historia medikoaren eta azterketa klinikoaren arabera diagnostikatzen dira. Larruazaleko biopsia, odol azterketa edo azterketa immunologikoak ere baliagarriak izan daitezke.
Erupzioa eragiten duten sendagai arrunten adibideak dira antibiotikoak eta beste mikrobioen aurkako sendagaiak, sulfa sendagaiak, antiinflamatorio ez-esteroideak (AINE), gaixotasun gaiztoetarako kimioterapiako agenteak, konbultsioen aurkakoak eta droga psikotropikoak.
○ Diagnostikoa eta Tratamendua
Sukarra baduzu (gorputzaren tenperatura igo), ahalik eta azkarren bilatu behar duzu medikuaren arreta. Ustezko sendagaia eten egin behar da (adibidez, antibiotikoak, antiinflamatorio ez-steroidalak). Ospitalera joan aurretik, ahozko antihistaminikoek, hala nola, cetirizina edo loratadina bezalako azkura eta rash lagun dezake.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Odol azterketa (CBC, LFT, eosinofiloen zenbaketa)
Ahozko esteroideak eta antihistaminikoak medikuaren errezetarekin