Dysplastic nevus - Nevo Displastikoa
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Dysplastic nevi – Mendebaldeko pertsonentzat biopsia gomendatzen da.
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ReferencesDysplastic nevus, atipikoa edo Clark's nevus bezala ere ezaguna, eztabaidak piztu ditu dermatologian eta dermatopatologian. Medikuek sarrak horiek biopsia egiten dituzte askotan, itxura anormala dutelako eta melanomaren inguruko kezkak sor ditzaketelako.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, atipiko edo Clark nevi izenez ere ezagunak, batzuetan melanoma sor dezakete. Melanoma % 36 inguruk nevi displasikoetatik gertu aurkitzen dira. Nevi displasiko bat melanoma bihur daitekeen seinaleak dira: forma irregularra, pigmentu aldaketa gehiago edo kolore grisaxka bat. Nevi hauek adin txikiagoetan gertatzen dira normalean (hogeita hamarreko hamarkadaren erdialdean), anitz izan daitezke eta askotan enborrean daude. Genetikoki, dysplastic nevi nevi onberak eta melanomaren artean daude. Hala ere, melanomaren % 20‑% 30 baino ez daude nebietatik datoz. Nebi gehienak melanoma bihurtzen ez dutelako, normalean ez da gomendagarria prebentzioz kentzea.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma melanozitoak, azalaren koloreaz arduratzen diren zelulak minbizi bihurtzen direnean sortzen den tumore mota bat da. Melanozitoak gandorra neuraletik sortzen dira. Horrek esan nahi du melanomak ez bakarrik azalean, baita gandor neuronalaren zelulak migratzen diren beste eremu batzuetan ere garatu daitezkeela; traktu gastrointestinala eta garuna, adibidez. Melanoma goiztiarreko (0. Fasea) duten pazienteen biziraupen-tasa %97 da, eta nabarmen jaisten da fase aurreratuko (IV. Fasea) gaixotasuna diagnostikatzen dutenen %10 ingurura.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Minbiziaren arriskua
Ameriketako Estatu Batuetako kasuetan ikusi den bezala, gizonetan, nevus displasikoak dituztenek bizitza osoan zehar melanoma garatzeko arriskua 10 % baino handiagoa dute. Aldiz, nevus displasikoak ez dituztenek melanoma garatzeko arriskua 1 % baino txikiagoa da.
○ Nevus displasikoak dituzten pertsonentzako neurriak
Larruazaleko auto-azterketa gomendatzen da melanoma prebenitzeko (kendu daitezkeen nebo atipikoak identifikatuz) edo dauden tumoreak goiz detektatzeko. Larruazaleko minbiziaren aurrekari pertsonalak edo familiarrak dituzten, edo nevo atipiko anitzak dituzten pertsonek dermatologo bat ikusi beharko lukete gutxienez urtean behin melanoma garatzen ari ez direla ziurtatzeko.
[ABCDE] laburdura baliagarria izan da osasun-hornitzaileei eta profanoei melanoma baten funtsezko ezaugarriak gogoratzen laguntzeko. Zoritxarrez, pertsona arruntentzat, keratosi seborreiko askok, lentigo senilis batzuk eta garatxoek ere [ABCDE] ezaugarriak izan ditzakete, eta ez dira melanoma batetik bereizi.
○ [ABCDE]
Asymmetrical: Larruazaleko lesio asimetrikoa.
Border: Lesioaren ertza irregularra da.
Color: Melanomek kolore irregular anitz izan ohi dute.
Diameter: 6 mm-tik gorako neboek melanomak izateko probabilitate handiagoa dute nebuen txikiagoak baino.
Evolution: Nevus edo lesio baten bilakaerak (hau da, aldaketa) lesioa gaizto bihurtzen ari dela adieraz dezake.