Herpes simplex - Herpes Sinplea
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Herpes simplex ezpainean.
Herpes Sinplea (Herpes simplex) ― Herpes simplex infekzioa behatzetan ohikoagoa da haur txikietan helduetan baino.
References
HSV-1 infekzioak zelula epitelialen infekzio primarioaren bidez egiten du aurrera, eta ondoren latentzia, batez ere neuronetan, eta berraktibazioa. HSV-1 normalean hasierako eta behin eta berriz erupzio besikularrak eragiten ditu, batez ere ahoan eta mukosan genitalean. Bere agerpenak herpes orolabialetik hainbat baldintzatara doaz, hala nola foliculitis herpetikoa, larruazaleko infekzioak, begietako inplikazioa eta herpes entzefalitisa bezalako kasu larriak. Terapia antibiralak HSV infekzioa kudeatzen laguntzen du.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 1 (HSV-1) is a member of the Alphaherpesviridae subfamily. Its structure is composed of linear dsDNA, an icosahedral capsid that is 100 to 110 nm in diameter, with a spikey envelope. In general, the pathogenesis of HSV-1 infection follows a cycle of primary infection of epithelial cells, latency primarily in neurons, and reactivation. HSV-1 is responsible for establishing primary and recurrent vesicular eruptions, primarily in the orolabial and genital mucosa. HSV-1 infection has a wide variety of presentations, including orolabial herpes, herpetic sycosis (HSV folliculitis), herpes gladiatorum, herpetic whitlow, ocular HSV infection, herpes encephalitis, Kaposi varicelliform eruption (eczema herpeticum), and severe or chronic HSV infection. Antiviral therapy limits the course of HSV infection.
Herpes simplex virus type 2 (HSV-2) hedatutako infekzioa da, 12 urtetik gorako helduen % 22 ingururi eragiten dio, Estatu Batuetan 45 milioi heldu guztira. HSV-1 normalean ahozko minak eragiten dituen arren, genitalen lesioak ere sor ditzake. Hala ere, pazienteek genitalen lesioak dituztenean, HSV-2 izan ohi da kezka nagusia. HSV-2 agerraldien sintomak lausoak izan ohi dira, genitalen azkura eta narritadura bezalakoak, diagnostikoa eta tratamendua atzeratu ditzaketenak. Atzerapen honek kutsatu gabeko pertsonei gehiago transmititzea eragin dezake.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus type 2 (HSV-2) continues to be a common infection, affecting approximately 22% of adults ages 12 and older, representing 45 million adults in the United States alone. While HSV-1 often affects the perioral region and can be known to cause genital lesions, HSV-2 is more commonly the consideration when patients present with genital lesions. Despite this, most outbreaks of the infection will present with nonspecific symptoms such as genital itching, irritation, and excoriations, which may cause diagnosis and treatment to be delayed. As a result, further exposure to uninfected individuals may occur.
Herpes simplex virus (HSV) normalean herpes genitala eta hotza bezalako infekzioak eragiten ditu nerabe eta helduengan. HSVk haur bat infektatzen duenean bizitzako lehen 4-6 asteetan, gaixotasun larria sor dezake ondorio larriak dituena. Jaioberrien HSV infekzioa azkar diagnostikatzea funtsezkoa da gaixotasuna okerrera ez dadin, arazo neurologikoak (baita heriotza ere) saihesteko.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex virus (HSV), a member of the Herpesviridae family, is a well-known cause of infections including genital herpes and herpes labialis in the adolescent and adult population. Transmission of HSV infection to an infant during the first 4-6 weeks of life can lead to devastating disease with the potential for poor outcomes. Early diagnosis is imperative when evaluating neonatal HSV infection in order to prevent further disease progression, neurological complications, and even death.
Herpes simplex infekzioa oso ohikoa da eta haurdun dauden emakumeetatik haurrei transmititu daiteke. Birus honek osasun arazo larriak edo heriotza eragin ditzake jaioberrietan. Haurdunaldian bertan arraroa den arren, sarritan erditzean gertatzen da. Arriskua handiena da ama haurdunaldiaren azken faseetan kutsatzen bada. Dena den, arrisku hori murriztu daiteke birusen aurkako sendagaiak erabiliz edo zenbait egoeratan cesar baten aldeko apustua eginez.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases.
Herpes simplex virus (HSV) 1 eta 2 motak jende asko kutsatzen dute mundu osoan. Normalean, birusa isilik egoten da nerbio-zeluletan larruazala kutsatu ondoren, baina geroago berriro aktibatu daiteke, hotza eraginez. Batzuetan, begien infekzioak, garuneko hantura edo baldintza arriskutsuak sortzen ditu jaioberriengan eta sistema immune ahula duten pertsonengan. Egungo sendagaiek infekzioak kontrolatzen laguntzen duten arren, sendagaien erresistentzia eta bigarren mailako efektu arriskuak kezkatzen jarraitzen du. Droga berriak behar ditugu birusa hobeto bideratzeko.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Infection with herpes simplex virus (HSV) types 1 and 2 is ubiquitous in the human population. Most commonly, virus replication is limited to the epithelia and establishes latency in enervating sensory neurons, reactivating periodically to produce localized recurrent lesions. However, these viruses can also cause severe disease such as recurrent keratitis leading potentially to blindness, as well as encephalitis, and systemic disease in neonates and immunocompromised patients. Although antiviral therapy has allowed continual and substantial improvement in the management of both primary and recurrent infections, resistance to currently available drugs and long-term toxicity pose a current and future threat that should be addressed through the development of new antiviral compounds directed against new targets.
Bi motatako herpes sinplea (herpes simplex) birusak daude, 1 mota (HSV-1) eta 2 mota (HSV-2). HSV-1ek normalean infekzioak eragiten ditu aho inguruan, eta HSV-2-k infekzio genitalak eragiten ditu. Kutsatutako gizabanakoarekin zuzeneko kontaktuaren bidez transmititzen dira. Herpes genitala sexu-transmisiozko infekzio gisa sailkatzen da. Erditzean haur bati hedatu daiteke. Infekzioaren ondoren, birusak nerbio sentsorialetan zehar garraiatzen dira nerbio-zelulen gorputzetara, non bizi osoan bizi diren. Errepikapenaren arrazoiak honako hauek izan daitezke: funtzio immune gutxitzea, estresa eta eguzki-argiaren esposizioa.
Kasu gehienetan, birusen aurkako sendagaiak sintomak larriak direnean bakarrik hartzen dira. Eguneroko birusen aurkako botika errezeta daiteke oso maiz infekzioa duen bati. Ez dago txertorik erabilgarri eta shingles txertoak ez du herpes simplex saihesten. Aciclovir edo valaciclovir bezalako botiken aurkako tratamenduek sintomen larritasuna gutxitu dezakete.
Mundu osoko HSV-1 edo HSV-2 tasak %60 eta %95 artekoak dira helduengan. HSV-1 normalean haurtzaroan kutsatzen da. Mundu osoan 536 milioi pertsona inguru (biztanleriaren % 16) HSV-2 kutsatuta zeuden 2003an, emakumeen eta garapen-bidean dauden herrialdeen artean tasa handiagoarekin. HSV-2 duten pertsona gehienak ez dira konturatzen kutsatuta daudela.
○ Tratamendua ― OTC Drogak
Saihestu edozein kontaktu fisikoa, hala nola haur bati musu ematea, babak dauden bitartean, kontaktuak beste pertsona batzuetara heda baitezake infekzioa. Alkoholik edan gabe atseden hartu behar duzu.
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