Livedoid vasculitis - Baskulitis Livedoidea
Baskulitis Livedoidea (Livedoid vasculitis) larruazaleko gaixotasun kroniko bat da, batez ere emakume gazte eta ertainekoetan ikusten dena. Bere ezaugarriak deskribatzeko erabiltzen den akronimo bat "Ultzera purpuriko mingarriak, beheko muturren erretikula-ereduarekin" (MORA) da. Gaixotasun ugarirekin lotuta dago, hipertentsio kronikoa eta barizeak barne.
☆ Alemaniako Stiftung Warentest-en 2022ko emaitzetan, ModelDerm-ekin kontsumitzaileen gogobetetasuna apur bat txikiagoa izan zen ordaindutako telemedikuntzako kontsultekin baino.
Minarekin batera izan daiteke.
References
Livedoid vasculopathy larruazaleko gaixotasun arraroa da, beheko hanketan itzultzen diren ultzera mingarriak dituena.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy larruazaleko gaixotasun arraroa da, beheko hanketan ultzerak errepikatzen dituena, atrophie blanche izenez ezagutzen diren orbain zurbilak utziz. Kausa zehatza oraindik argi ez dagoen arren, uste da odolaren koagulazioa areagotzea (hypercoagulability) dela faktore nagusia, hanturak bigarren mailako papera betetzen duela. Koagulazioan laguntzen duten faktoreak honako hauek dira - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Biopsietan, egoera horrek odol-koaguluak erakusten ditu hodien barruan, ontzien hormen loditzea eta orbainak. Tratamenduak ikuspegi anitzeko ikuspegia dakar, odol-koaguluak prebenitzera bideratua, plaketa-kontrako sendagaiekin, odol-dilutzaileak eta terapia fibrinolitikoa bezalako botikekin. Larruazaleko egoera honetarako hainbat sendagai erabil daitezke - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy bi hanketan lesioak gertatzen diren baldintza arraroa da. Odol-hodi txikietan odol-koaguluen sorrera koagulazioa areagotzearen eta koagulazioaren matxura murriztearen ondorioz gertatzen dela uste da, ontziaren estaldura kaltetuarekin batera. Emakumezkoetan ohikoagoa da, batez ere 15 eta 50 urte bitartekoen artean. Erretzeari uztea, zauriak zaintzea eta odol-diluatzaileak eta plaketarren aurkako sendagaiak bezalako botikak erabiltzea eraginkorra izan da.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
