Onychomysosis - Azazkalen Onddoa
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Azazkalen Onddoa (Onychomysosis)-k eragindako oinetako iltzea
Iltze onddoen infekzioa duen pertsona baten oina hamar astetan terbinafina ahozko botikaren ikastaro batean. Kontuan izan kutsatutako gainerako iltzeen atzean dagoen iltze osasuntsuaren hazkuntza banda.
References
Antifungiko sistemikoak tratamendu eraginkorrena dira. Metaanalisiek sendatze mikotikoen tasak honela erakusten dituzte: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Iltze desbridatzeak are gehiago areagotzen ditu sendatze tasak. Terapia topikoa ciclopirox -rekin ez da hain eraginkorra; %60tik gorako porrot-tasa du.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Onikomikosia iltzeei eragiten dien onddoen infekzioa da. Dermatofitoek eragindakoa denean, tinea unguium deitzen zaio. Onikomikosiak dermatofitoek, legamiek eta lizunek eragindako infekzioak barne hartzen ditu. Onddoen infekzio batek eragiten ez duen iltze-arazo bati nail dystrophy deitzen zaio. Azazkalak zein oinetakoak eragina izan dezakeen arren, oinetako onikomikosia ohikoagoa da. Artikulu honek oinetako onikomikosiaren hainbat alderdi aztertzen ditu, hala nola, bere eragina, mota klinikoak, faseak, diagnostikoa eta tratamendua. Bizitza arriskuan jartzen ez den arren, onikomikosiak konplikazio larriak ekar ditzake zelulitisa, sepsia, hezur-infekzioa, ehunen kaltea eta iltzeak galtzea.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Terbinafine onddoen infekzioei aurre egiten dien botika da, squaleno epoxidasa blokeatuz. Larruazaleko onddo mota askoren aurka eraginkorra da eta iltze onddoak tratatzeko onartuta dago ahoz hartzen denean. Buruko mina eta urdaileko arazoak bezalako bigarren mailako efektu gehienak txikiak diren eta bere kabuz desagertzen diren arren, zapore aldaketak (disgeusia) arinetatik larrietara alda daitezke, eta batzuetan pisua galtzen dute. Zapore aldaketa iraunkorrak arraroak dira, baina jakinarazi dira.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Onikomikosia iltzeak eragiten dituen onddoen infekzioa da. Oinetako azazkalen infekzioen % 90 inguru eta azazkalen infekzioen % 75 inguru onddoek eragiten dute (Trichophyton mentagrophytes, Trichophyton rubrum) . Sintomak azazkalen kolorea, loditzea, iltze ohetik bereiztea eta gehiegizko hazkuntza dira. Tratamenduak normalean terbinafina edo itraconazole bezalako ahozko botikak izaten ditu, tratamendu topikoak kasu arin edo moderatuen aukera izanik.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Ahoan hartutako terbinafina antifungikoen botika eraginkorrena dela dirudi, baina terbinafina gibelaren bigarren mailako efektuarekin lotuta dago.
azazkalen onddoa (onychomysosis) helduen biztanleriaren ehuneko 10ean gertatzen da, eta adinekoek maizago eragiten dute. Gizonezkoek emakumezkoek baino maizago eragiten dute. azazkalen onddoa (onychomysosis) iltze-gaixotasunaren erdia da. Horrek esan nahi du oinetako azazkalen deformazioa onikomikosia ez den beste arrazoi batzuetatik ere etor daitekeela.
○ Tratamendua ― OTC Drogak
Zaila da botika topikoekin onikomikosia tratatzea, sendagaiak oinetako azazkalak lodituetan sartzea zaila delako.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Tratamendua
Epe luzeko tratamendua behar izaten da kutsatutako oinetako iltzea guztiz kendu arte.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer