Informazio gehiago ― Euskalduna

Erythema nodosum is the most common form of panniculitis and is characterized by tender erythematous nodules mainly in the lower limbs on the pretibial area. The exact cause of erythema nodosum is unknown, although it appears to be a hypersensitivity response to a variety of antigenic stimuli. Although the etiology is mostly idiopathic, ruling out an underlying disease is imperative before diagnosing primary erythema nodosum. Erythema nodosum can be the first sign of a systemic disease that is triggered by a large group of processes, such as infections, inflammatory diseases, neoplasia, and/or drugs. The most common identifiable causes are streptococcal infections, primary tuberculosis, sarcoidosis, Behçet disease, inflammatory bowel disease, drugs, and pregnancy.

Panniculitis larruazalpeko gantz-ehuna barne hartzen duten hanturazko gaixotasunen talde heterogeneo bat osatzen dute. Nahaste hauek arraroak dira haurrengan. Panikulitisa nahaste sistemiko baten lehen prozesua izan daiteke edo infekzio, traumatismo edo botiken ondoriozko bigarren mailako prozesu bat izan daiteke. Panikulitis mota gehienek aurkezpen kliniko bera dute (eziologia edozein dela ere) , larruazalpeko nodulu samur eta eritematosoekin.
Panniculitides form a heterogenous group of inflammatory diseases that involve the subcutaneous adipose tissue. These disorders are rare in children and have many aetiologies. As in adults, the panniculitis can be the primary process in a systemic disorder or a secondary process that results from infection, trauma or exposure to medication. Some types of panniculitis are seen more commonly or exclusively in children, and several new entities have been described in recent years. Most types of panniculitis have the same clinical presentation (regardless of the aetiology), with tender, erythematous subcutaneous nodules.

Panniculitis , larruazalpeko gantzaren hantura, normalean hanturazko noduluekin agertzen da. Erythema nodosum (EN) klinikoki panikulitis formarik ohikoena da. EN-ren % 55 arte idiopatikotzat jotzen den arren, kausa ohikoenak infekzioak, drogak, gaixotasun sistemikoak, hala nola sarkoidosia eta hesteetako hanturazko gaixotasunak, haurdunaldia eta gaiztoak dira. EN normalean nerabe eta 20ko hamarkadan agertzen da, eta emakumezkoetan ikusten da maizago. Askotan astebete edo hiru aste arteko prodromo ez-espezifikoa izan ohi da, eta horrek sukarra, gaitza eta goiko arnasbideetako infekzio baten sintomak izan ditzake. Ondoren, larruazal-lesioak jarraitzen dira, normalean gorputz-adarraren hedapen-alderdian kokatuta. Lesio mingarriak biribilduak edo obalatuak dira, apur bat goratuak, ultzeragarriak ez diren nodulu gorriak. EN-en patogenia zehatza ez da ulertzen, nahiz eta larruazalpeko gantzetan septae benuletan konplexu immuneak jalkitzearen ondorioz sortu dela uste dena, panikulitis neutrofilo bat eragiten duela. Egoera kausatibo baterako terapia espezifikorik gabe ere, EN tratamendurik gabe konpontzen da kasu gehienetan.
Panniculitis, inflammation of the subcutaneous fat, usually presents with inflammatory nodules. Erythema nodosum (EN) is clinically the most frequent form of panniculitis. Whilst up to 55% of EN is considered idiopathic, the most common causes include infections, drugs, systemic illnesses such as sarcoidosis and inflammatory bowel disease, pregnancy, and malignancy. EN typically presents in the teens and 20s, and is seen more commonly in females. It is often preceded by a non-specific prodrome of one to three weeks, which may include fever, malaise, and symptoms of an upper respiratory tract infection. Cutaneous lesions then follow, typically localized on the extensor aspect of the limbs. The lesions are painful rounded or oval, slightly raised, non-ulcerative red nodules. The exact pathogenesis of EN is not understood, although is thought to result from deposition of immune complexes in the venules of the septae in subcutaneous fat, causing a neutrophilic panniculitis. Even without specific therapy for a causative condition, EN resolves without treatment in most cases.