Porokeratosis - Porokeratosia
☆ Alemaniako Stiftung Warentest-en 2022ko emaitzetan, ModelDerm-ekin kontsumitzaileen gogobetetasuna apur bat txikiagoa izan zen ordaindutako telemedikuntzako kontsultekin baino.
Irten diren ertz gogorrak ezaugarriak dira.
References
Porokeratosis keratinizazio-arazoak dituen larruazaleko gaixotasun arraroa da, eta larruazalean eraztun-formako orban goratuak edo kolpe latzak sortzen ditu. Mikroskopioan definitzen duen ezaugarria kornoide lamelaren presentzia da, azalaren goiko geruzako zelulen antolamendu espezifikoa. Porokeratosis hainbat formatan dator, hala nola disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Garrantzitsua da kontuan izan porokeratosis azaleko minbizia bihur daitekeela. Porokeratosis diagnostikatzeko modurik onena ertz altxatuaren biopsia egitea da, nahiz eta gaur egun ez dagoen tratamendu-protokolo estandarrik.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) keratinizazio desordenatuaren gaixotasuna da. Sei porokeratosi motatako bat da, eta normalean eremu handiagoak eragiten ditu besteekin alderatuta (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis) . Porokeratosi mota eruptiboa minbiziarekin, immunitate ahulduarekin edo hanturarekin lotzen da. Arrisku-faktoreek genetika, immunodepresioa eta eguzki-esposizioa dira. DSAP kolpe arrosa edo marroi gisa hasten da ertz altxatuak eguzkitan jarritako eremuetan, batzuetan azkura arina eragiten du. Tratamenduak aldatu egiten dira eta gaurkotasuneko kremak, argi terapia edo 5-fluorouracil edo retinoideak bezalako botikak izan ditzakete. Lesio hauek minbizi aurrekotzat hartzen dira, eta 7. 5 - 10 %-ko aukera dute kartzinoma ezkamotsu edo basozelular bihurtzeko.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
52 urteko gizon bat, lehen osasuntsu, laugarren behatzaren muturrean eraztun itxurako adabaki lau batekin sartu zen, 2 urte zeramatzana sintomarik sortu gabe. Kolpe txiki eta gogor gisa hasi zen eta denborarekin kanpora hazi zen. Krioterapia, kremak, antifungikoak eta antibiotikoak bezalako hainbat tratamendu probatu arren, adabakia ez zen hobetu. Dermokopsiarekin gertutik aztertuta, ertz lodi eta zakarra zuen erdigune lehor eta gorria ikusi zen. Adabakiaren ertzetik hartutako larruazaleko zati txiki batek larruazaleko kanpoko geruzan zelulen hazkunde anormala erakutsi zuen, porokeratosis of Mibelli diagnostikoa baieztatuz.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Askotan biopsia egiten da, keratosi aktinikoaren edo kartzinoma ezkamotsuaren antzekoa izan daitekeelako.