Porokeratosis
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Saksan vuoden 2022 Stiftung Warentest -tuloksissa kuluttajien tyytyväisyys ModelDermiin oli vain hieman alhaisempi kuin maksullisiin telelääketieteen konsultaatioihin.
Saksan vuoden 2022 Stiftung Warentest -tuloksissa kuluttajien tyytyväisyys ModelDermiin oli vain hieman alhaisempi kuin maksullisiin telelääketieteen konsultaatioihin.
Kovat, ulkonevat reunat ovat ominaisia.
relevance score : -100.0%
ReferencesPorokeratosis on harvinainen ihosairaus, jolle on tunnusomaista keratinisaatio-ongelmat, jotka johtavat kohoaviin, renkaanmuotoisiin laikkuihin tai karkeisiin kuhmuihin iholla. Sen määrittävä piirre mikroskopian alla on kornoidilamelli, joka on erityinen solujen järjestely ihon pintakerroksessa. Porokeratosis esiintyy eri muodoissa, kuten disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum ja linear porokeratosis. On tärkeää huomata, että porokeratosis voi kehittyä ihosyöväksi. Paras tapa diagnosoida porokeratosis on biopsia kohotetusta reunasta, vaikka tällä hetkellä ei ole olemassa standardoitua hoitoprotokollaa.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated superficial actinic porokeratosis (DSAP) on epäsäännöllisen keratinisoitumisen sairaus. Se on yksi kuudesta porokeratoosityypistä, ja se vaikuttaa tyypillisesti suurempiin alueisiin verrattuna muihin (linear, Mibelli's, punctate, palmoplantar disseminated, and superficial porokeratosis). Porokeratoosin eruptiivinen tyyppi liittyy usein syöpään, heikentyneeseen immuniteettiin tai tulehdukseen. Riskitekijöihin kuuluvat genetiikka, immuunivasteen heikkeneminen ja auringolle altistuminen. DSAP alkaa vaaleanpunaisina tai ruskeina kuoppina, joissa on kohotetut reunat auringolle alttiilla alueilla, mikä joskus aiheuttaa lievää kutinaa. Hoidot vaihtelevat ja voivat sisältää paikallisia voiteita, valohoitoa tai lääkkeitä, kuten 5-fluorouracil tai retinoideja. Näitä vaurioita pidetään syöpää edeltävinä, ja 7,5–10 %:n mahdollisuus muuttua okasolu- tai tyvisolusyöväksi.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Aiemmin terve 52‑vuotias mies tuli vastaanotolle litteänä, rengasmaisena laastarina neljännen varpaan päässä, joka oli ollut paikallaan kaksi vuotta ilman oireita. Se alkoi pienenä, kovakuorisena nystyränä ja kasvoi ajan myötä ulospäin. Laastaria on kokeiltu erilaisilla hoidoilla, kuten kryoterapialla, voiteilla, sienilääkkeillä ja antibiooteilla, mutta se ei ole parantunut. Dermokopsialla tarkasteltuna havaittiin kuiva, punainen keskusta, jonka reunat olivat paksut ja karheat. Laastarin reunasta otettu pieni näyte ihosta osoitti epänormaalia solukasvua ihon ulkokerroksessa, mikä vahvisti diagnoosin porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Biopsia tehdään usein, koska se voi näyttää samankaltaiselta kuin aktiininen keratoosi tai levyepiteelisyöpä.