Amyloidosis - Amyloidose
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Klassike gesichtsfunksjes fan Amyloidose (Amyloidosis)
References
In 26-jierrige frou kaam nei ús klinyk en klage oer in jeukende útslach op har skonken dy't se 10 jier hie hân. Nettsjinsteande it brûken fan steroide crèmes en tazarotene-crème, waard de útslach net better. Se hie gjin relevante famyljeskiednis. Doe't wy har ûndersochten, fûnen wy ferhege, rûge plakken op 'e foarkant fan har skonken, dy't oerienkomme mei in sykte neamd lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Lichen Amyloidosis is in seldsume hûdbetingsten ferbûn mei oanhâldende jeuk fan ûnbekende oarsaak. It ferskynt typysk as klusters fan ferhege, ferkleure plakken op 'e bûtenste oerflakken fan' e hûd. Lichen Amyloidosis komt normaal foar by minsken fan 50 oant 60 jier en spitigernôch is d'r gjin genêzing foar. Behannelingen dy't no beskikber binne wurkje normaal net goed.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen amyloidosis is in lang duorjende jeukende hûdbetingsten. It is bekend om klusters fan dikke bulten dy't benammen fûn wurde op 'e rêch, skonken, dijen en earms. As ûndersocht ûnder in mikroskoop, Lichen amyloidosis toant in opbou fan amyloïde yn 'e boppeste hûdlaach tegearre mei ferdikking en fergrutting fan' e bûtenste hûdlaach. Hoewol de krekte oarsaak fan Lichen amyloidosis noch net folslein begrepen is, hawwe eardere stúdzjes it keppele oan faktoaren lykas wrijven of wriuwing op 'e hûd, seldea, virale ynfeksjes, ûnder oaren. Lichen amyloidosis liket keppele te wêzen mei ferskate oare hûdomstannichheden (atopic dermatitis, lichen planus, mycosis fungoides) .
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnose en behanneling
#Electrophoresis of blood or urine
#Skin biopsy