Dysplastic nevus - Dysplastyske Nevus
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Dysplastic nevi – biopsie wurdt oanrikkemandearre.
relevance score : -100.0%
ReferencesDysplastic nevus, ek wol bekend as in atypyske of Clarks nevus, hat debatten yn dermatology en dermatopathology opsmite. Dokters nimme faak in biopsie fan dizze molles, omdat se abnormaal lykje en soargen meitsje oer melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastic nevi, ek bekend as atypysk of Clark nevi, kinne soms liede ta melanoma. Ungefear 36 % fan melanomen wurdt fûn tichtby dysplastyske nevi. Skaaimerken dat in dysplastyske nevus kin feroarje yn melanoma omfetsje in unjildige foarm, mear pigmentferoarings, of in griisige kleur. Dizze kankers komme normaal foar op in jongere leeftyd (om de midden fan de tritiger jierren), kinne meardere wêze, en binne faak op de romp. Genetysk sit dysplastic nevi tusken goedaardige nevi en melanoma. Mar 20 % oant 30 % fan melanomen komme fan besteande nevi. Om't de measte nevi gjin melanoma wurde, wurdt it normaal net oan te rieden om se preventyf te ferwiderjen.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Melanoma is in soarte fan tumor dy't ûntstiet as melanozyten, sellen ferantwurdlik foar hûdkleur, en kin kankere. Melanozyten ûntsteane út 'e neural crest. Dit betsjut dat melanomen net allinich op 'e hûd kinne ûntwikkelje, mar ek yn oare gebieten wêr't neuronale krystsellen migrearje, lykas it gastrointestinale traktaat en harsens. It oerlibjensnivo foar pasjinten mei melanoma yn 'e iere faze (stadium 0) is heech, 97%, wylst it signifikant sakket nei sawat 10% foar dyjigen dy't diagnostearre binne mei sykte yn in avansearre stadium (stadium IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Kankerrisiko
Lykas sjoen by Kaukasyske persoanen yn de Feriene Steaten, hawwe minsken mei dysplastyske nevi in libbensrisiko op it ûntwikkeljen fan melanoma fan mear as 10 %. Oan de oare kant hawwe persoanen sûnder dysplastyske nevus in risiko fan minder as 1 %.
○ Foarsoarch foar persoanen mei dysplastyske nevi
Hûdselûndersyk wurdt meastentiids oanrikkemandearre om melanoma foar te kommen (troch atypyske nevi te identifisearjen dy't ferwiderd wurde kinne) of om bestaande tumoren betiid te detektearjen. Minsken mei in persoanlike of famyljeskiednis fan hûdkanker of mei meardere atypyske nevi moatte op syn minst ien kear yn it jier in dermatolooch sjen om der wis fan te wêzen dat se gjin melanoma ûntwikkelje.
De ôfkoarting [ABCDE] is nuttich om sûnenssoarchferlieners en leken te helpen by it ûndersykjen fan de wichtichste skaaimerken fan in melanoma. Spitigernôch kinne by de measte minsken seborrheic keratoses, guon lentigo senilis, en sels wratten [ABCDE]-skaaimerken sjen litte, wêrtroch se net altyd fan in melanoma te ûnderskieden binne.
○ [ABCDE]
Asymmetrical: Asymmetryske hûdlesie.
Border: De grins fan de lesje is ûnregelmjittich.
Color: Melanomen hawwe meastentiids meardere ûnregelmjittige kleuren.
Diameter: Nevi grutter as 6 mm hawwe in hegere kâns op melanoma dan lytsere nevi.
Evolution: De evolúsje (d.w.s. feroaring) fan in nevus of lesje kin oanjaan dat de lesje malign wurdt.