Mear ynformaasje ― Frysk

Erythema multiforme (EM) is in betingst wêryn ûnderskiedende doel-like flekken ferskine op sawol de hûd as de slijmvliezen fanwegen immuunreaksjes. Hoewol faaks feroarsake troch virale ynfeksjes, benammen herpes simplex-firus (HSV), of bepaalde medisinen, bliuwt de oarsaak yn in protte gefallen ûnbekend. De behanneling fan akute EM rjochtet him op it ferminderjen fan symptomen mei help fan crèmes dy't steroids as antihistamines befetsje. It behearjen fan weromkommende EM is it meast effektyf as it is ôfstimd op elke pasjint. Inisjele oanpak omfettet sawol orale as topikale behannelingen. Dizze omfetsje corticosteroids en antiviral medisinen. Aktuele behannelingen besteane út sterke steroid crèmes en oplossings foar troffen slijmvliezen. Foar pasjinten dy't net reagearje op antivirale, omfetsje twadde-line opsjes immuunûnderdrukke medisinen, antibiotika, anthelmintika en antimalaria.
Erythema multiforme (EM) is an immune-mediated condition that classically presents with discrete targetoid lesions and can involve both mucosal and cutaneous sites. While EM is typically preceded by viral infections, most notably herpes simplex virus (HSV), and certain medications, a large portion of cases are due to an unidentifiable cause. Treatment for acute EM is focused on relieving symptoms with topical steroids or antihistamines. Treatment for recurrent EM is most successful when tailored to individual patients. First line treatment for recurrent EM includes both systemic and topical therapies. Systemic therapies include corticosteroid therapy and antiviral prophylaxis. Topical therapies include high-potency corticosteroids, and antiseptic or anesthetic solutions for mucosal involvement. Second-line therapies for patients who do not respond to antiviral medications include immunosuppressive agents, antibiotics, anthelmintics, and antimalarials

Yn in protte gefallen giet milde erythema multiforme binnen 2 oant 4 wiken op himsels. Stevens‑Johnson‑syndroom, in slim tastân dat invloed hat op slijmvliezen, kin oant 6 wiken duorje. Steroïden wurde net typysk oanrikkemandearre foar milde gefallen. Of steroïden brûkt wurde moatte foar swiere erythema multiforme is net wis, om't der gjin dúdlike befiningen binne fan randomisearre stúdzjes dy’t oanjaan hokker pasjinten profitearje fan dizze behanneling.
In most cases, mild erythema multiforme is self-limited and resolves in 2 to 4 weeks. Stevens-Johnson syndrome is a serious disease that involves the mucous membranes and lasts up to 6 weeks. There is no indication for using steroids for the mild form. Use of steroids for erythema multiforme major is debatable because no randomized studies clearly indicate which children will benefit from this treatment.

Wy presintearje in gefal fan mûnlinge erythema multiforme (EM) feroarsake troch TMP/SMX, mei typyske mûnlinge- en lippe-ulcera sûnder hûdlesjes. Dit ûnderstrekt de needsaak om oare mûnlinge ulcerative steuringen te ûnderskieden. De pasjint krige symptomatyske behanneling en prednisolon-tabletten, wat liede ta ferbettering nei it stopjen fan de TMP/SMX-terapy.
We report a case of oral erythema multiforme (EM) secondary to TMP/SMX that presented with oral and lip ulcerations typical of EM without any skin lesions and highlights the importance of distinguishing them from other ulcerative disorders involving oral cavity. The patient was treated symptomatically and given tablet prednisolone. The condition improved with stoppage of TMP/SMX therapy.

Erythema multiforme is in reaksje wêrby't de hûd en soms de slijmvliezen belutsen is, triggere troch it immúnsysteem. Typysk manifestearret it as doel-achtige lesjes, dy't kin ferskine as isolearre, weromkommende of oanhâldende. Dizze lesjes beynfloedzje normaal symmetrisch de úteinen, benammen de bûtenste oerflakken. De wichtichste oarsaken omfetsje ynfeksjes lykas herpes simplex-virus en Mycoplasma pneumoniae, bepaalde medisinen, immunisaasjes en auto‑immune sykten. It ûnderskieden fan erythema multiforme en urticaria hinget ôf fan de duer fan de lesjes; erythema multiforme‑lesjes bliuwe fêst foar op syn minst sân dagen, wylst urticaria‑lesjes faak binnen in dei ferdwine. Hoewol ferlykber, is it krúsjaal om erythema multiforme te ûnderskieden fan it ernstiger Stevens‑Johnson‑syndroom, dat typysk wijdverspreide erythematous of purpuryske macules mei blieren presintearret. Behear fan erythema multiforme omfettet symptomatysk reliëf mei topike steroïden of antistamininen en it oanpakken fan de ûnderlizzende oarsaak. Foar weromkommende gefallen ferbûn mei herpes simplex-virus wurdt profylaktyske antivirale terapy oanrikkemandearre. Swiere mucosale belutsenens kin sikehûsopname nedich wêze foar intraveneuze floeden en elektrolytferfanging.
Erythema multiforme is a reaction involving the skin and sometimes the mucosa, triggered by the immune system. Typically, it manifests as target-like lesions, which may appear isolated, recur, or persist. These lesions usually symmetrically affect the extremities, particularly their outer surfaces. The main causes include infections like herpes simplex virus and Mycoplasma pneumoniae, as well as certain medications, immunizations, and autoimmune diseases. Distinguishing erythema multiforme from urticaria relies on the duration of lesions; erythema multiforme lesions remain fixed for at least seven days, while urticarial lesions often vanish within a day. Although similar, it's crucial to differentiate erythema multiforme from the more severe Stevens-Johnson syndrome, which typically presents widespread erythematous or purpuric macules with blisters. Managing erythema multiforme involves symptomatic relief with topical steroids or antihistamines and addressing the underlying cause. For recurrent cases associated with herpes simplex virus, prophylactic antiviral therapy is recommended. Severe mucosal involvement may necessitate hospitalization for intravenous fluids and electrolyte replacement.