Intraepithelial carcinoma (Bowen disease) - Intraepithelial Carcinoma (Bowen Sykte)
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Typysk gefal ― Intraepithelial Carcinoma (Bowen Sykte) (Intraepithelial carcinoma (Bowen disease)) kin ferkeard diagnostearre wurde as in lang duorjende, net-jeukende eczeem.
References
Bowen's disease (BD) is in soarte hûdkanker dat begjint yn 'e bûtenste laach fan' e hûd (epidermis) . It komt faker foar yn Kaukasiërs en komt faak foar yn gebieten dy't bleatsteld binne oan sinneljocht, mar it kin ek earne oars ferskine. BD ferskynt typysk as in inkele lesion. BD wurdt faak sjoen as in warskôgingsteken foardat in mear serieuze soarte fan hûdkanker ûntwikkelt. Om BD te diagnostearjen, fertrouwe dokters gewoanlik op it ûndersykjen fan weefselmonsters ûnder in mikroskoop (biopsy) .
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease (BD) is an in-situ squamous cell carcinoma of epidermis. The etiology of BD is multifactorial with high incidence among Caucasians. BD is common in photo-exposed areas of skin, but other sites can also be involved. Lesions are usually solitary. The morphology of BD differs based on age of the lesion, site of origin, and the degree of keratinization. BD is considered as the lull before the storm, which precedes an overt squamous cell carcinoma. Histopathology is the gold standard diagnostic modality to confirm the diagnosis.
Bowen's disease beynfloedet meast blanke persoanen fan âlder dan 60. Wichtige risikofaktoaren omfetsje lange-termyn bleatstelling oan sinne, ferswakke ymmúnsysteem, bleatstelling oan arseen, en HPV-ynfeksje fan 'e hûd. HPV-stammen 16, 18, 34 en 48 binne keppele oan de sykte fan Bowen yn genitalgebieten. De belutsenens fan HPV yn net-genitale gefallen is minder dúdlik.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
Bowen disease is most commonly found in white patients over 60 years old. Other risk factors include chronic sun exposure, immunosuppression, arsenic exposure and cutaneous human papillomavirus (HPV) infection. HPV types 16, 18, 34 and 48 cause Bowen disease at genital sites; the role of HPV in nongenital cases of Bowen disease is less well defined. HPV types 2, 16, 34 and 35 have been rarely identified within nongenital lesions.
It ferskynt meastentiids as in erythematous, scaly of crusty gebiet oeral op it lichem. De meast foarkommende lokaasje is legere skonken.
It is te genêzen troch ferskate behannelingopsjes lykas kryoterapy, curettage, cautery, fotodynamyske terapy, of útsûndering fan 'e lesion.
○ Diagnose en behanneling
#Dermoscopy
#Skin biopsy
#Mohs surgery
#Photodynamic therapy