Keloid
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Yn 'e 2022 Stiftung Warentest-resultaten út Dútslân wie de konsuminttefredenheid mei ModelDerm mar wat leger dan mei betelle telemedisynkonsultaasjes.
Yn 'e 2022 Stiftung Warentest-resultaten út Dútslân wie de konsuminttefredenheid mei ModelDerm mar wat leger dan mei betelle telemedisynkonsultaasjes.
In postoperatieve keloïd op de pols waard behannele mei in intralesionale triamcinolone‑ynjeksje. It sonken erytheemgebiet oan de linkerkant is it behannele gebiet.
Lineêre keloïden. As se foarkomme op de boppekant fan de romp, ferskine se faak yn lineêre foarm.
Posterior auricular Keloid (Posterior auriculêre keloïd)
Keloïden op de soallen fan de fuotten kinne ûngemaklik wêze om op te rinnen. Yntralesionale steroïde ynjeksjes wurde meastens ferskate kearen útfierd.
Keloïden wurden faak waarnommen op de boppeste earm.
Typyske manifestaasje fan boarstkeloïden.
relevance score : -100.0%
ReferencesKeloïden foarmje troch ûngewoane genêzing nei hûdblessuere of ûntstekking. Genetyske en omjouwingsfaktoaren drage by oan har ûntwikkeling, mei hegere tariven yn yndividuen mei donkere hûd fan Afrikaanske, Aziatyske en Hispanyske komôf. Keloïden ferskine as fibroblasten oeraktyf wurde, wêrtroch oermjittich kollagen en groeifaktoaren produsearre wurde. Dit liedt ta de formaasje fan grutte, abnormale kollagenbondels, bekend as keloidal kollagen, tegearre mei in ferheging fan fibroblasten. Klinysk ferskine keloïden as fêste, rubberige nodules yn gebieten dy't earder ferwûne binne. Oars as normale littekens útwreidzje keloïden bûten de oarspronklike trauma‑lokaasje. Pasjinten kinne pine, jeuk of brânen ûnderfine. Ferskate behannelingen binne beskikber, ynklusyf steroide‑ynjeksjes, kryoterapy, sjirurgy, radiotherapy en laser‑terapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
It hjoeddeiske ûndersyk suggerearret dat siliconengel of blêden tegearre mei corticosteroid‑ynjeksjes de foarkar is foar keloïden. Oanfoljende behannelingen lykas intralesional 5-fluorouracil (5‑FU), bleomycin of verapamil kinne ek wurde beskôge, hoewol har effektiviteit ferskilt. Laserterapy, kombinearre mei corticosteroid‑ynjeksjes of topikale steroïden ûnder occlusie, kin de penetraasje fan medisinen ferbetterje. Foar recalcitrante keloïden is sjirurgyske ferwidering, folge troch direkte bestralingstherapy, oanwiisd effektyf te wêzen. Uteinlik is it brûken fan siliconenblêden en drukterapy bewiisd om de weromkomst fan keloïden te ferminderjen.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Op it stuit is d'r gjin ien-grutte-past-all-behanneling dy't in konsekwint leech werhellingsnivo garandearret foar keloïden. De groeiende opsjes, lykas it brûken fan lasers neist steroïden of it kombinearjen fan 5-fluorouracil mei steroïden, litte lykwols belofte sjen. Takomstich ûndersyk kin rjochtsje op hoe goed nije behannelingen, lykas autologe fet grafting of stamcel-basearre terapyen, wurkje foar it behearen fan keloïden.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
Littekens binne in mienskiplik ûnderdiel fan it genêzingsproses nei hûdblessueres. Ideaal moatte littekens flak, dun en by de hûdskleur passe. In protte faktoaren kinne liede ta minne wûne genezing, lykas ynfeksje, fermindere bloedstream, ischemia en trauma. Littekens dy't dik, donkerder binne as de omlizzende hûd, of oermjittich krimpje kinne wichtige problemen feroarsaakje foar sawol fysike funksje as emosjonele sûnens.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Keloïde littekens wurde faker sjoen by minsken fan Afrikaanske, Aziatyske of Hispanyske komôf. Minsken tusken de 10 en 30 jier hawwe in hegere kâns om in keloid te ûntwikkeljen as âldere minsken.
Hoewol't se meastal foarkomme op it plak fan in blessuere, kin in keloid ek spontaan ûntstean. Se kinne ferskine by piercings en sels by wat sa ienfâldich as in pimple of kras. Se kinne ûntstean as gefolch fan akne of waterpokken‑littekens, ynfeksje op in wûne, trauma oan in gebiet, oermjitte hûdspanning by wondsluten, of in frjemd lichem yn in wûne.
Keloïde littekens kinne ûntstean nei operaasje. Se komme faker foar op guon plakken, lykas de sintrale boarst (bij sternotomie), de rêch en skouders (meastentiids as gefolch fan akne), en de earlellen (bij earpiercings). Se kinne ek foarkomme by lichemspiercings. De meast foarkommende plakken binne earlellen, earms, bekkenregio, en de kraachbonke.
Beskikbere behannelingen binne drukterapy, siliconengelblêden, intra‑lesionale triamcinoloneacetonide, kryochirurgie, strieling, laserterapy, Interferon, 5‑FU en sjirurgyske útsûndering.
○ Behanneling
Hypertrofyske littekens kinne ferbettere wurde mei 5 oant 10 intra‑lesionale steroïd‑ynjeksjes yn in moanne‑ynterfal.
#Triamcinolone intralesional injection
Laserbehanneling kin brûkt wurde foar erythema ferbûn mei littekens, en triamcinolone‑ynjeksjes kinne it erytema ferbetterje troch it litteken te platten.
#Dye laser (e.g. V‑beam)