Porokeratosis
https://en.wikipedia.org/wiki/Porokeratosis
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De hurde útspringende rânen binne karakteristyk.
relevance score : -100.0%
References
Porokeratosis 30335323 NIH
Porokeratosis is in seldsume hûdbetingsten karakterisearre troch keratinisaasjeproblemen, wat resulteart yn ferhege, ringfoarmige plakken as rûge bulten op 'e hûd. Syn definiearjende skaaimerk ûnder de mikroskoop is de oanwêzigens fan cornoid lamella, in spesifike opstelling fan sellen yn 'e boppeste laach fan' e hûd. Porokeratosis komt yn ferskate foarmen (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . It is wichtich om te notearjen dat porokeratosis potinsjeel kin ûntwikkelje ta hûdkanker. De bêste manier om porokeratosis te diagnostearjen is troch in biopsie fan 'e ferhege grins, hoewol d'r op it stuit gjin standert behannelingprotokol is.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Disseminated Superficial Actinic Porokeratosis 29083728 NIH
Disseminated superficial actinic porokeratosis (DSAP) is in sykte fan steurde keratinisaasje. It is ien fan seis soarten porokeratosis, en it hat typysk ynfloed op gruttere gebieten yn ferliking mei de oaren (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . De eruptive soarte fan porokeratosis ferbynt faak mei kanker, ferswakke ymmuniteit, of ûntstekking. Risikofaktoaren omfetsje genetika, ymmúnûnderdrukking, en bleatstelling oan sinne. DSAP begjint as rôze of brune bulten mei ferhege rânen yn sinne bleatstelde gebieten, soms feroarsaakje lichte jeuk. Behannelingen fariearje en kinne topyske crèmes, ljochtterapy, of medisinen lykas 5-fluorouracil of retinoïden omfetsje. Dizze lesions wurde beskôge as precancerous, mei in 7. 5 - 10 % kâns om te feroarjen yn squamous cell of basale cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Porokeratosis of Mibelli - Case reports 33150040 NIH
In 52-jierrige man, earder sûn, kaam binnen mei in platte, ringfoarmige plak op 'e ein fan syn fjirde tean, dy't der al 2 jier siet sûnder symptomen te feroarsaakjen. It begûn as in lytse, hurde bult en groeide nei bûten ta. Nettsjinsteande it besykjen fan ferskate behannelingen lykas kryoterapy, crèmes, antifungalen en antibiotika, waard de patch net better. It nau ûndersiikjen mei in dermokopsy toande in droech, read sintrum mei in dikke, rûge grins. In lyts stikje hûd nommen fan 'e râne fan' e patch toande abnormale selgroei yn 'e bûtenste laach fan' e hûd, befêstiget in diagnoaze fan porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Faak wurdt in biopsie útfierd, om't it fergelykber kin wêze mei aktinyske keratose of squamous cell carcinoma.