Syphilis - Syfilis
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Chancres ― primêre syfilityske ynfeksje troch Treponema pallidum
References
Syfilis is in seksueel oerdraachbere sykte dy't feroarsake wurdt troch de baktearje Treponema pallidum. Yn dizze stúdzje rjochtsje wy ús op 57 pasjinten fan 18-68 jier mei sekundêre syfilis.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Venereal syphilis is a multi-stage, sexually transmitted disease caused by the spirochetal bacterium Treponema pallidum (Tp). Herein we describe a cohort of 57 patients (age 18-68 years) with secondary syphilis (SS) identified through a network of public sector primary health care providers in Cali, Colombia.
Syfilis is in baktearjele ynfeksje feroarsake troch Treponema pallidum. It kin ferskate sykten imitearje, en fertsjinnet it de bynamme great imitator. Syfilis beynfloedet noch miljoenen wrâldwiid, mar kin effektyf behannele wurde mei penisilline.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Syphilis is a systemic bacterial infection caused by the spirochete Treponema pallidum. Due to its many protean clinical manifestations, it has been named the “great imitator and mimicker.” Syphilis remains a contemporary plague that continues to afflict millions of people worldwide. Luckily, the causative organism is still sensitive to penicillin.
Treponema pallidum feroarsake syfilis troch seksueel kontakt of fan mem nei poppe tidens swangerskip. Ek al binne d'r ienfâldige tests om it te diagnostearjen en behanneling mei ien langwerkende penisilline-shot goed wurket, syfilis wurdt wrâldwiid wer in grut probleem. Dit is benammen wier ûnder manlju dy't seks hawwe mei manlju (MSM) yn lannen mei hege en middelste ynkommen. Wylst guon lannen mei leech ynkommen de WHO-doelen foldien hawwe om te stopjen dat syfilis fan mem nei poppe oergiet, is d'r in soarchlike opkomst yn syfilis ûnder HIV-positive MSM.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
Treponema pallidum subspecies pallidum (T. pallidum) causes syphilis via sexual exposure or via vertical transmission during pregnancy. Despite the availability of simple diagnostic tests and the effectiveness of treatment with a single dose of long-acting penicillin, syphilis is re-emerging as a global public health problem, particularly among men who have sex with men (MSM) in high-income and middle-income countries. Although several low-income countries have achieved WHO targets for the elimination of congenital syphilis, an alarming increase in the prevalence of syphilis in HIV-infected MSM serves as a strong reminder of the tenacity of T. pallidum as a pathogen.
(1) Fergrutte lever: Dit wurdt faak fûn en kin barre neist in fergrutte milt. Undersykjen fan in leverbiopsy ûnder donkerfjildmikroskopie kin de oanwêzigens fan 'e spirochete sjen litte. Tests foar leverfunksje kinne abnormaliteiten sjen litte. (2) Yellowing of the Skin (Jaundice) : Oft immen toant jaundice hinget ôf fan hoefolle de lever wurdt beynfloede. (3) Runny Nose: Faak ien fan 'e earste tekens, meast binnen de earste wike nei berte. (4) Swollen lymfeknoten: Generalisearre swelling fan lymfeknoten, meast pynlik, is ek gewoan. (5) Skin Rash: In útslach ferskynt typysk ien oant twa wiken nei de rinnende noas. Jo kinne lytse reade of rôze flekken sjen op 'e rêch, billen, dijen en soallen fan' e fuotten. Dizze útslach kin trochrinne ta peeling en crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
(1) Hepatomegaly: This is the most common finding and may occur with splenomegaly. Biopsy of the liver followed by darkfield microscopy may reveal the spirochete. Liver function tests may be abnormal. (2) Jaundice: Jaundice may or may not be present depending on the extent of liver injury. (3) Rhinitis: One of the first clinical presentations, usually in the first week of life. Copious, persistent white discharge is noted, which contains spirochetes that can be visualized under darkfield microscopy. (4) Generalized Lymphadenopathy: Generalized, non-tender lymphadenopathy is also a common finding. (5) Rash: Rash usually appears one to two weeks after rhinitis. Small red or pink colored maculopapular lesions may be commonly seen on the back, buttocks, posterior thigh and soles of the feet. The rash progresses to desquamation and crusting.
○ Diagnose en behanneling
VDRL en RPR kinne brûkt wurde om resinte ynfeksje te befêstigjen en skerm foar syfilis. FTA-ABS test is in mear spesifike test en kin brûkt wurde om te kontrolearjen foar eardere ynfeksje skiednis. Penicilline wurdt brûkt foar de behanneling fan syfilis.