Acute generalized exanthematous pustulosis - Pustulosis Exanthematous Ginearálaithe Géarmhíochaine
Is imoibriú annamh craicinn é Pustulosis Exanthematous Ginearálaithe Géarmhíochaine (Acute generalized exanthematous pustulosis) (AGEP) a bhaineann le riarachán cógas i 90% de na cásanna. Is sainairíonna é pustulosis exanthematous ginearálaithe géarmhíochaine (acute generalized exanthematous pustulosis) brúchtaí tobanna craiceann a thagann le feiceáil cúig lá ar an meán tar éis tús a chur le cógas. Is pustules iad na brúchtaí seo, i.e. brúchtadh beag dearg bán nó dearg ar an gcraiceann ina bhfuil ábhar scamallach nó purulentach (pus). De ghnáth réitíonn na loit chraicinn laistigh de 1-3 lá tar éis stop a chur leis an gcógas ciontaithe.
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Is cosúil go tobann loit fhorleathan le héiritime agus pustules.
References
Is imoibriú craicinn é Acute generalized exanthematous pustulosis (AGEP) atá marcáilte le bumps beaga líonta púitsí ar bhonn dearg craiceann. Tarlaíonn sé de ghnáth nuair a ghlacann duine cógais áirithe, amhail antaibheathaigh, agus go scaipeann sé go tapa ar fud an choirp. Tar éis stop a chur leis an gcógas spreagtha, imíonn na hairíonna de ghnáth laistigh de dhá sheachtain, rud a fhágann go bhfuil roinnt shedding craicinn ann go minic. Cé nach mbíonn siad tromchúiseach agus teoranta don chraiceann de ghnáth, is féidir cásanna tromchúiseacha a chur in iúl in éineacht le frithghníomhartha tromchúiseacha craicinn eile amhail Stevens-Johnson syndrome nó toxic epidermal necrolysis. Is cúram tacaíochta go príomha é an chóireáil, agus is gnách go mbíonn an prognóis le haghaidh réiteach iomlán an ghalair den scoth.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Tháinig fear 76 bliain d'aois go dtí an seomra éigeandála mar go raibh athrú tagtha ar a chraiceann le dhá lá anuas. Fuair dochtúirí paistí dearga agus limistéir ardaithe ar a stoc agus ar a lámha agus ar a chosa. De réir mar a chuaigh an t-am ar aghaidh, tháinig na paistí seo le chéile, agus d'fhorbair sé bumps cosúil le pimple sna limistéir dhearga. Thaispeáin na tástálacha go raibh ard-áireamh cille fola bán ann le go leor de chineál ar a dtugtar neodrófilí, agus leibhéil ardaithe C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
