Drug eruption - Brúchtadh Drugaí
☆ I dtorthaí 2022 Stiftung Warentest ón nGearmáin, ní raibh sástacht na dtomhaltóirí le ModelDerm ach beagán níos ísle ná mar a bhí le comhairliúchán teileamhíochaine íoctha.
Tá Brúchtadh Drugaí (Drug eruption) tréithrithe ag cur isteach ar an gcorp ar fad.
References
Is féidir le frithghníomhartha craicinn de bharr cógais, ar a dtugtar brúchtaí drugaí, a bheith dian uaireanta. Meastar go bhfuil na frithghníomhartha tromchúiseacha seo, ar a dtugtar severe cutaneous adverse drug reactions (SCARs) , bagrach don bheatha. Áirítear leo coinníollacha mar Stevens-Johnson syndrome (SJS) , toxic epidermal necrolysis (TEN) , acute generalized exanthematous pustulosis (AGEP) , and drug reaction with eosinophilia and systemic symptoms (DRESS) . Cé gur annamh a bhíonn SCARs , bíonn taithí ag thart ar 2% d’othair san ospidéal orthu.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Adverse drug reactions involving the skin are commonly known as drug eruptions. Severe drug eruption may cause severe cutaneous adverse drug reactions (SCARs), which are considered to be fatal and life-threatening, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). Although cases are relatively rare, approximately 2% of hospitalized patients are affected by SCARs.
Thug bean 31 bliain d'aois cuairt ar an roinn deirmeolaíochta le paiste dearg gan phian ar bharr a coise deise. Ghlac sí dáileog amháin de doxycycline (100 mg) an lá roimhe, tar éis cóireála léasair picosecond do scars acne. Anuraidh, bhain sí fadhb den chineál céanna sa láthair chéanna tar éis di an dáileog chéanna de chóireáil iar-léasair doxycycline a ghlacadh. Níl aon stair shuntasach leighis aici agus níl aon airíonna eile aici, mar fhiabhras, go háitiúil nó ar fud a colainne.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
A 31-year-old woman presented to the dermatology department with an asymptomatic erythematous patch on the dorsum of her right foot. She had taken 1 dose of doxycycline (100 mg) the previous day as empirical treatment after picosecond laser treatment for acne scars. She had had a similar episode the previous year on the same site, after taking the same dose of doxycycline after laser treatment. She had no notable medical history, and no other local or systemic symptoms, including fever.
Is dhá chineál d’fhrithghníomh tromchúiseach craicinn iad Stevens-Johnson syndrome (SJS) agus toxic epidermal necrolysis (TEN) , atá éagsúil ó riochtaí craicinn eile amhail mórshiondróm craiceann scaldáilte éiritime multiforme agus stafalacocais, chomh maith le frithghníomhartha drugaí. Is frithghníomh annamh agus trom é SJS/TEN a dhéanann damáiste forleathan don chraiceann agus don membrane múcasach, go minic le hairíonna sistéamacha. I níos mó ná 80% de na cásanna, is iad míochainí an chúis.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are variants of the same condition and are distinct from erythema multiforme major staphylococcal scalded skin syndrome, and other drug eruptions. Stevens-Johnson syndrome/toxic epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and mucosal loss accompanied by systemic symptoms. Medications are causative in over 80% of cases.
Déantar brúchtaí drugaí a dhiagnóisiú go príomha ón stair liachta agus ón scrúdú cliniciúil. Is féidir le bithóipse craicinn, tástálacha fola nó tástálacha imdhíoneolaíocha a bheith úsáideach freisin.
Samplaí de dhrugaí coitianta is cúis leis an brúchtadh tá antaibheathaigh agus drugaí frithmhiocróbacha eile, drugaí sulfa, drugaí frith-athlastach neamhsteroidal (NSAIDs), gníomhairí ceimiteiripeacha le haghaidh urchóideacha, frith-thalamháin agus drugaí síceatrópacha.
○ Diagnóis agus Cóireáil
Má tá fiabhras ort (teocht an chomhlachta méadaithe), ba cheart duit aire leighis a lorg a luaithe is féidir. Ba cheart scor den druga amhrasta (m.sh. antaibheathaigh, drugaí frith-athlastach neamhstéaróideach). Sula dtugann siad cuairt ar an ospidéal, d'fhéadfadh frithhistamíní béil mar cetirizine nó loratadine cabhrú le tochas agus gríos.
#Cetirizine [Zytec]
#LevoCetirizine [Xyzal]
#Loratadine [Claritin]
Tástáil fola (CBC, LFT, comhaireamh eosinophil)
Stéaróidigh ó bhéal agus frithhistamíní le oideas dochtúra