Keloid
https://en.wikipedia.org/wiki/Keloid
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References
Keloid 29939676 NIH
Is foirm keloids de bharr cneasaithe neamhghnácha tar éis gortú craiceann nó athlasadh. Cuireann fachtóirí géiniteacha agus comhshaoil lena bhforbairt, le rátaí níos airde i ndaoine aonair a bhfuil craiceann dorcha orthu ó shliocht Afracach, Áise agus Hispanic. Tarlaíonn keloids nuair a éiríonn fibroblasts róghníomhach, rud a tháirgeann fachtóirí iomarcacha collagen agus fás. Mar thoradh air seo cruthaítear babhtaí collaigine móra neamhghnácha, ar a dtugtar collagen keloidal, chomh maith le méadú ar fibroblasts. Go cliniciúil, feictear keloids mar nodúlacha daingean, rubairithe i gceantair a gortaíodh roimhe seo. Murab ionann le gnáth-scars, leathnaíonn keloids níos faide ná an suíomh tráma bunaidh. D’fhéadfadh pian, itching nó dó a bheith ag an othar. Tá cóireálacha éagsúla ar fáil, lena n-áirítear insteallaí stéaróideacha, criotairipe, máinliacht, radaiteiripe agus teiripe léasú.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Keloid treatments: an evidence-based systematic review of recent advances 36918908 NIH
Tugann an taighde reatha le fios gur é glóthach nó leatháin silicone, chomh maith le hinstealltaí corticosteroid, an chóireáil tosaigh is fearr le haghaidh keloids. Is féidir cóireálacha breise cosúil le 5-fluorouracil intralesional (5-FU), bleomycin, nó verapamil a mheas freisin, cé go n-athraíonn a n-éifeachtúlacht. Is féidir le teiripe léasair, nuair a dhéantar é a chomhcheangal le hinstealltaí corticosteroid nó stéaróidí tráthúla faoi occlusion, dul i bhfód le feabhsú na drugaí. Maidir le keloids athchomhairliúcháin, tá sé léirithe go bhfuil baint mháinliachta agus teiripe radaíochta láithreach éifeachtach. Ar deireadh, tá sé cruthaithe go laghdaítear an dóchúlacht go dtarlóidh atarlú keloid trí úsáid a bhaint as leatháin silicone agus teiripe brú.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Keloids: a review of therapeutic management 32905614 NIH
Faoi láthair, níl aon chóireáil aon-mhéide ann a ráthaíonn ráta atarlaithe comhsheasmhach íseal do keloids. Mar sin féin, tá roghanna ag fás, cosúil le léasair a úsáid le stéaróidí nó 5-fluorouracil a chomhcheangal le stéaróidí, le gealltanais. D’fhéadfadh taighde amach anseo díriú ar cé chomh maith a oibríonn cóireálacha nua, mar ghreamú saille uathlógach nó teiripí gás-cheall-bhunaithe, chun keloids a bhainistiú.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
Scar Revision 31194458 NIH
Is cuid choitianta den phróiseas cneasaithe iad cicinn tar éis gortuithe craiceann. Go hidéalach, ba chóir go mbeadh cicinn cothrom, tanaí, agus dath craicinn a mheaitseáil. Is féidir droch-chneasaithe créachta a bheith mar thoradh ar go leor fachtóirí, mar ionfhabhtú, sreabhadh fola laghdaithe, ischemia, agus tráma. Is féidir le cicinn atá tiubh, níos dorcha ná an craiceann timpeall, nó a chrapadh ró-mhór, fadhbanna suntasacha a chruthú i dtéarmaí feidhme fisiciúil agus sláinte mhothúchánach.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Is féidir feabhas a chur ar scairteanna hipertrófa le 5 go 10 ionchur steroid intralesional, 1 eagrán gach mí.
#Triamcinolone intralesional injection
Is féidir cóireáil léasair a thriail le haghaidh éiritime a bhaineann le scarring, ach is féidir le ionchuranna triamcinolone an éiritime a fheabhsú tríd an scar a leá.
#Dye laser (e.g. V-beam)