Keloid
☆ I dtorthaí 2022 Stiftung Warentest ón nGearmáin, ní raibh sástacht na dtomhaltóirí le ModelDerm ach beagán níos ísle ná mar a bhí le comhairliúchán teileamhíochaine íoctha.
A keloid postoperative ar an wrist cóireáilte le instealladh intralesional triamcinolone. Is é an limistéar éiritime bháite ar an taobh clé an limistéar cóireáilte.
Keloids Líneach. Nuair a tharlaíonn siad ar thaobh tosaigh uachtarach an torso, is minic a bhíonn siad le feiceáil i gcruth líneach.
posterior auricular Keloid
Is féidir le Keloids ar boinn na cosa a bheith míchompordach chun siúl ar. Instealladh steroid Intralesional dhéantar de ghnáth arís agus arís eile.
keloids breathnaítear go coitianta ar na lámha uachtair.
Léiriú tipiciúil de keloids cófra.
References
Foirm keloids de bharr cneasaithe neamhghnácha tar éis gortú craiceann nó athlasadh. Cuireann fachtóirí géiniteacha agus comhshaoil lena bhforbairt, le rátaí níos airde i ndaoine aonair a bhfuil craiceann dorcha orthu de shliocht Afracach, Áiseach agus Hispanic. Tarlaíonn keloids nuair a éiríonn fibroblasts róghníomhach, rud a tháirgeann fachtóirí iomarcacha collagen agus fáis. Mar thoradh air seo cruthaítear babhtaí collaigine móra neamhghnácha ar a dtugtar collagen keloidal, chomh maith le méadú ar fibroblasts. Go cliniciúil, feictear keloids mar nodules daingean, rubairithe i gceantair a gortaíodh roimhe seo. Murab ionann agus gnáth-scars, leathnaíonn keloids níos faide ná an suíomh tráma bunaidh. D’fhéadfadh pian, itching nó dó a bheith ag othair. Tá cóireálacha éagsúla ar fáil, lena n-áirítear instealltaí stéaróideacha, criiteiripe, máinliacht, radaiteiripe agus teiripe léasair.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Keloids result from abnormal wound healing in response to skin trauma or inflammation. Keloid development rests on genetic and environmental factors. Higher incidences are seen in darker skinned individuals of African, Asian, and Hispanic descent. Overactive fibroblasts producing high amounts of collagen and growth factors are implicated in the pathogenesis of keloids. As a result, classic histologic findings demonstrate large, abnormal, hyalinized bundles of collagen referred to as keloidal collagen and numerous fibroblasts. Keloids present clinically as firm, rubbery nodules in an area of prior injury to the skin. In contrast to normal or hypertrophic scars, keloidal tissue extends beyond the initial site of trauma. Patients may complain of pain, itching, or burning. Multiple treatment modalities exist although none are uniformly successful. The most common treatments include intralesional or topical steroids, cryotherapy, surgical excision, radiotherapy, and laser therapy.
Tugann an taighde reatha le fios gurb é glóthach nó leatháin silicone chomh maith le instealltaí corticosteroid an chóireáil tosaigh is fearr le haghaidh keloids. Is féidir cóireálacha breise cosúil le 5-fluorouracil intralesional (5-FU) , bleomycin, nó verapamil a mheas freisin, cé go n-athraíonn a n-éifeachtacht. Is féidir le teiripe léasair, nuair a dhéantar é a chomhcheangal le hinstealltaí corticosteroid nó stéaróidigh tráthúla faoi occlusion, dul i bhfód drugaí a fheabhsú. Maidir le keloids athchomhairliúcháin, tá sé léirithe go bhfuil baint máinliachta agus teiripe radaíochta láithreach éifeachtach. Ar deireadh, tá sé cruthaithe go laghdaítear an dóchúlacht go dtarlóidh atarlú keloid trí úsáid a bhaint as leatháin silicone agus teiripe brú.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Current literature supports silicone gel or sheeting with corticosteroid injections as first-line therapy for keloids. Adjuvant intralesional 5-fluorouracil (5-FU), bleomycin, or verapamil can be considered, although mixed results have been reported with each. Laser therapy can be used in combination with intralesional corticosteroids or topical steroids with occlusion to improve drug penetration. Excision of keloids with immediate post-excision radiation therapy is an effective option for recalcitrant lesions. Finally, silicone sheeting and pressure therapy have evidence for reducing keloid recurrence.
Faoi láthair, níl aon chóireáil aon-mhéide ann a ráthaíonn ráta atarlaithe comhsheasmhach íseal do keloids. Mar sin féin, tá na roghanna atá ag fás, cosúil le léasair a úsáid taobh le stéaróidigh nó 5-fluorouracil a chomhcheangal le stéaróidigh, geallta. D’fhéadfadh taighde amach anseo díriú ar cé chomh maith agus a oibríonn cóireálacha nua, mar ghreamú saille uathlógach nó teiripí gascheall-bhunaithe, chun keloids a bhainistiú.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
There continues to be no gold standard of treatment that provides a consistently low recurrence rate; however the increasing number of available treatments and synergistic combinations of these treatments (i.e., laser-based devices in combination with intralesional steroids, or 5-fluorouracil in combination with steroid therapy) is showing favorable results. Future studies could target the efficacy of novel treatment modalities (i.e., autologous fat grafting or stem cell-based therapies) for keloid management.
Is cuid choitianta den phróiseas cneasaithe iad scars tar éis gortuithe craiceann. Go hidéalach, ba chóir go mbeadh scars cothrom, tanaí, agus dath craiceann a mheaitseáil. Is féidir droch-chneasaithe créachta a bheith mar thoradh ar go leor fachtóirí, mar ionfhabhtú, sreabhadh fola laghdaithe, ischemia, agus tráma. Is féidir le scaranna atá tiubh, níos dorcha ná an craiceann mórthimpeall, nó a chrapadh ró-mhór fadhbanna suntasacha a chruthú maidir le feidhm fhisiciúil agus sláinte mhothúchánach.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Scars are a natural and normal part of healing following an injury to the integumentary system. Ideally, scars should be flat, narrow, and color-matched. Several factors can contribute to poor wound healing. These include but are not limited to infection, poor blood flow, ischemia, and trauma. Proliferative, hyperpigmented, or contracted scars can cause serious problems with both function and emotional well-being.
Feictear scars keloid níos minice i ndaoine de shliocht Afracach, Áiseach nó Hispanic. Tá claonadh níos airde ag daoine idir 10 agus 30 bliain d'aois keloid a fhorbairt ná daoine scothaosta.
Cé go dtarlaíonn siad go hiondúil ar shuíomh gortaithe, is féidir keloid teacht chun cinn go spontáineach freisin. Is féidir leo tarlú ar shuíomh pollta agus fiú ó rud éigin chomh simplí le pimple nó scratch. Is féidir leo tarlú mar thoradh ar acne tromchúiseach nó scarring deilgneach, ionfhabhtú ar shuíomh créachta, tráma arís agus arís eile go dtí limistéar, teannas craiceann iomarcach le linn dúnadh créachta nó comhlacht eachtrach i bhfoirceannadh.
Is féidir le scars keloid a fhorbairt tar éis máinliachta. Tá siad níos coitianta i roinnt suíomhanna, mar shampla an cófra lárnach (ó sternotomy), an chúl agus na guaillí (de ghnáth mar thoradh ar acne), agus na lobes cluaise (ó piercings cluaise). Is féidir leo tarlú freisin ar tholladh coirp. Is iad na spotaí is coitianta ná earlobes, airm, réigiún pelvic, agus os cionn cnámh an choiléar.
Is iad na cóireálacha atá ar fáil ná brú-teiripe, leatháin glóthacha silicone, aicéatóníd triamcinolone laistigh den lesion, crió-mháinliacht, radaíocht, teiripe léasair, Interferon, 5-FU agus múchadh máinliachta.
○ Cóireáil
Is féidir feabhas a chur ar scars hipertrófa le 5 go 10 n-instealladh steroid intralesional 1 eatramh 1 mhí.
#Triamcinolone intralesional injection
Is féidir cóireáil léasair a thriail le haghaidh éiritime a bhaineann le scarring, ach is féidir le instealltaí triamcinilone an éiritime a fheabhsú tríd an scar a leá.
#Dye laser (e.g. V-beam)