Onychomysosis - Fungas Toenail
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A toenail tionchar ag Fungas Toenail (Onychomysosis)
Cos duine a bhfuil ionfhabhtú fungasach ingne air nó uirthi deich seachtaine isteach i gcúrsa cógas béil terbinafine. Tabhair faoi deara an banna d'fhás ingne sláintiúil taobh thiar de na tairní ionfhabhtaithe atá fágtha.
References
Is iad antifungals sistéamach an chóireáil is éifeachtaí. Léiríonn meitianailísí rátaí leigheas mycotic mar a leanas: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Méadaíonn díbridiú ingne comhchéimneach rátaí leigheas a thuilleadh. Ní bhíonn teiripe tráthúla le ciclopirox chomh héifeachtach; tá ráta teip níos mó ná 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Is ionfhabhtú fungasach é onychomycosis a théann i bhfeidhm ar na tairní. Nuair is dermatophytes is cúis leis, tugtar tinea unguium air. Áirítear onychomycosis ionfhabhtuithe de bharr dermatophytes, giosta, agus múnla. Tugtar nail dystrophy ar fhadhb ingne nach cúis le hionfhabhtú fungach í. Cé gur féidir leis cur isteach ar mhéara agus toenails araon, tá onychomycosis toenail níos coitianta. Pléann an t-alt seo gnéithe éagsúla de onychomycosis toenail, mar a thionchar, cineálacha cliniciúla, céimeanna, diagnóis agus cóireáil. Cé nach bhfuil sé bagrach don bheatha, d’fhéadfadh deacrachtaí tromchúiseacha a bheith mar thoradh ar onychomycosis amhail cellulitis, sepsis, ionfhabhtú cnámh, damáiste fíocháin, agus caillteanas ingne.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Is cógas é Terbinafine a throideann ionfhabhtuithe fungacha trí squalene epoxidase a bhlocáil. Tá sé éifeachtach i gcoinne go leor cineálacha fungais chraiceann agus tá sé ceadaithe chun fungas ingne a chóireáil nuair a thógtar é ó bhéal. Cé gur beag fo-iarmhairtí ar nós tinneas cinn agus fadhbanna boilg agus go n-imíonn siad leo féin, is féidir le hathruithe ar bhlas (dysgeusia) a bheith éagsúil ó éadrom go dian, rud a fhágann cailliúint meáchain uaireanta. Is annamh a bhíonn athruithe blas buana ach tuairiscítear iad.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Is ionfhabhtú fungasach é onychomycosis a théann i bhfeidhm ar tairní. Is iad fungais (Trichophyton mentagrophytes, Trichophyton rubrum) is cúis le timpeall 90% d’ionfhabhtuithe toenail agus 75% d’ionfhabhtuithe méar. I measc na comharthaí tá dídhathú ingne, ramhrú, scaradh ón leaba ingne, agus rófhás. Is gnách go mbíonn cógais ó bhéal mar terbinafine nó itraconazole i gceist le cóireáil, agus is rogha iad cóireálacha tráthúla do chásanna éadroma nó measartha.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Is cosúil gurb é an terbinafine cógais antifungal a thógann béal an ceann is éifeachtaí ach tá baint ag terbinafine le fo-éifeacht an ae.
Tarlaíonn fungas toenail (onychomysosis) i thart ar 10 faoin gcéad den daonra fásta, agus is minice a chuirtear isteach ar dhaoine scothaosta. Cuirtear isteach ar fhir níos minice ná ar mhná. Is ionann fungas toenail (onychomysosis) agus thart ar leath den ghalar ingne. Ciallaíonn sé seo gur féidir le deformity na toenails teacht freisin ó chúiseanna seachas onychomycosis.
○ Cóireáil - Drugaí OTC
Tá sé deacair onychomycosis a chóireáil le míochainí tráthúla mar go bhfuil sé deacair do dhrugaí dul i ngleic leis na tairní tiubhaithe.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ Cóireáil
De ghnáth bíonn gá le cóireáil fhadtéarmach go dtí go mbaintear amach an toenail ionfhabhtaithe go hiomlán.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer