Porokeratosis
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Is saintréith iad na himill chrua protruding.
References
Is riocht annamh é Porokeratosis ar an gcraiceann arb é is sainairíonna ann fadhbanna ceirtíneacha, rud a fhágann go mbíonn paistí ardaithe, fáinne-chruthach nó bumps garbh ar an gcraiceann. Is é a ghné shainithe faoin micreascóp láithreacht lamella cornoid, socrú sonrach de chealla i gciseal barr an chraiceann. Tagann Porokeratosis i bhfoirmeacha éagsúla (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis) . Tá sé tábhachtach a thabhairt faoi deara go bhféadfadh porokeratosis forbairt ina ailse craicinn. Is é an bealach is fearr chun porokeratosis a dhiagnóiseadh ná bithóipse den teorainn ardaithe, cé nach bhfuil aon phrótacal cóireála caighdeánach ann faoi láthair.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Is galar de keratinization neamhord é Disseminated superficial actinic porokeratosis (DSAP) . Tá sé ar cheann de shé chineál porokeratosis, agus de ghnáth bíonn tionchar aige ar limistéir níos mó i gcomparáid leis na cinn eile (linear, Mibelli's, punctate, palmoplantar disseminated, superficial porokeratosis) . Is minic a nascann an cineál eruptive porokeratosis le hailse, díolúine lagú, nó athlasadh. Baineann fachtóirí riosca le géineolaíocht, cosc imdhíonachta, agus nochtadh na gréine. Tosaíonn DSAP mar bumps bándearg nó donn le imill ardaithe i limistéir ghrian-nochta, uaireanta is cúis le tochas beag. Athraíonn na cóireálacha agus d’fhéadfadh go n-áireofaí leo uachtair tráthúla, teiripe solais, nó cógais mar 5-fluorouracil nó retinoids. Meastar na loit seo a bheith réamhailse, agus seans 7. 5 - 10 % go n-iompóidh siad ina charcanóma cille squamous nó cille basal.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Tháinig fear 52 bliain d'aois, a bhí sláintiúil roimhe seo, isteach le paiste cothrom, fáinne-chruthach ar dheireadh a cheathrú ladhar, a bhí ann ar feadh 2 bhliain gan aon chomharthaí a chruthú. Thosaigh sé mar bump beag, crua agus d'fhás amach le himeacht ama. In ainneoin cóireálacha éagsúla a thriail mar chriiteiripe, uachtair, antifungals, agus antaibheathaigh, níor tháinig feabhas ar an bpaiste. Agus é a scrúdú go dlúth le dermocopsy léirigh ionad tirim, dearg le teorainn tiubh, garbh. Léirigh píosa beag bídeach craiceann a tógadh ó imeall an phaiste fás cille neamhghnácha i gciseal seachtrach an chraiceann, rud a dhearbhaigh diagnóis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Is minic a dhéantar bithóipse toisc go bhféadfadh sé breathnú cosúil le keratosis actinic nó carcinoma cille squamous.