Porokeratosis
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ReferencesIs riocht annamh é Porokeratosis ar an gcraiceann, a charactairízítear le papúla beag, cruthanna fáinneacha nó léachtaí crúbach ar an gcraiceann. Is é a ghné shainithe faoi mhicreascóp láithreacht lamha cornoid, socrú speisialta de chailíní i gciseal barr an chraiceann. Tagann Porokeratosis i bhfoirmeacha éagsúla (disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, linear porokeratosis). Tá sé tábhachtach a thabhairt faoi deara go bhféadfadh porokeratosis forbairt a dhéanamh ina ailse chraicinn. Is é an bealach is fearr chun porokeratosis a diagnóis ná biopsa den teorainn ardaithe, cé nach bhfuil aon phrótacal cóireála caighdeánach ann faoi láthair.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Porokeratosis is an uncommon dermatologic disorder. It is a disorder of keratinization that presents with keratotic papules or annular plaques with an elevated border. It has a distinct histologic hallmark of cornoid lamella, which is a column of tightly fitted parakeratotic cells in the upper epidermis. There are multiple clinical variants of porokeratosis, including disseminated superficial actinic porokeratosis, classical porokeratosis of Mibelli, porokeratosis palmaris plantaris et disseminatum, and linear porokeratosis. Porokeratosis is a precancerous lesion that can undergo malignant transformation. Evaluation of porokeratosis is best with a biopsy of the elevated border. There are no standard guidelines for treatment.
Is galar de dhíchumrú keratinization é Disseminated superficial actinic porokeratosis (DSAP). Tá sé ar cheann de na cineálacha porokeratosis, agus de ghnáth bíonn tionchar aige ar limistéir níos mó i gcomparáid leis na cinn eile (linear, porokeratosis of Mibelli (Mibelli), punctate, porokeratosis palmaris et plantaris disseminata, disseminated superficial porokeratosis). Is minic a nascann an cineál eruptive porokeratosis le hailse, imdhíonacht, nó athlasadh. Baineann fachtóirí riosca le géineolaíocht, imdhíonacht, agus nochtadh na gréine. Tosaíonn DSAP mar bumpanna bándearg nó donn le imill ardaithe i limistéir faoi ghréine, uaireanta is cúis le tochas beag. Athraíonn na cóireálacha agus d’fhéadfadh go n-áireofaí leo cóireálacha uachtair, teiripe solais, nó cógais mar 5-fluorouracil (5-FU) nó retinoids. Meastar na lésaí seo a bheith réamhailse, agus seans 7.5-10% go n-iompóidh siad ina charcair squamous nó cille bhunúsach.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Disseminated superficial actinic porokeratosis (DSAP) is a disease of disordered keratinization. Disseminated superficial actinic porokeratosis is one of six variants of porokeratosis. It has more extensive involvement than most other variants. These other variants include linear porokeratosis, porokeratosis of Mibelli, punctate porokeratosis, porokeratosis palmaris et plantaris disseminata, and disseminated superficial porokeratosis. The eruptive form of porokeratosis is associated with malignancy, immunosuppression, and a proinflammatory state. Risk factors for porokeratosis include genetics, immunosuppression, and ultraviolet light. The lesions in disseminated superficial actinic porokeratosis start as pink to brown papules and macules with a raised border in sun-exposed areas that can be asymptomatic or slightly pruritic. There are many options for the treatment of disseminated superficial actinic porokeratosis, including topical diclofenac, photodynamic therapy (PDT), 5-fluorouracil (5-FU), imiquimod, vitamin D analogs, retinoids, and lasers. These lesions are considered precancerous. There is a 7.5 to 10% risk of malignant transformation to squamous cell carcinoma or basal cell carcinoma.
Tháinig fear 52 bliain d'aois, a bhí sláintiúil roimhe seo, isteach le paiste cothrom, fáinne crúbach ar dheireadh a cheathrú ladhar, a bhí ann ar feadh 2 bhliain gan aon chomharthaí a chruthú. Thosaigh sé mar bump beag, crua agus d'fhás amach le himeacht ama. In ainneoin cóireálacha éagsúla a thriail mar chríotherapy, corticosteroids uachtaracha, antifungals, agus antibheathach, níor tháinig feabhas ar an bpáiste. Agus é a scrúdú go dlúth le dermoscóip léirigh ionad tirim, dearg le teorainn tiubh, garbh. Léirigh píosa beag craicinn a tógadh ó imeall an pháiste fás cill neamhghnácha i gciseal seachtrach an chraicinn, rud a dhearbhaigh diagnóis porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
A 52-year-old man with no past medical history presented with an asymptomatic annular atrophic patch on the distal portion of the fourth toe of 2 years’ duration. The lesion began as a small keratotic papule that gradually enlarged centrifugally. He had received multiple treatments including cryotherapy, topical corticosteroids, antifungals, and antibiotics without improvement. Dermoscopic examination revealed a scaly atrophic erythematous central area with a sharply demarcated peripheral hyperkeratotic structure. A skin biopsy of the edge of the lesion revealed a cornoid lamella with a column of parakeratotic cells extending from an invagination of the epidermis with absence of granular layer. The clinicopathologic correlation was consistent with porokeratosis of Mibelli.
Is minic a dhéantar biopsí toisc go bhféadfadh na leisiúin breathnú cosúil le keratosis actinic (actinic keratosis) nó carcinoma squamous (squamous cell carcinoma).