Acute generalized exanthematous pustulosis
Tha Acute generalized exanthematous pustulosis (AGEP) na ath-bhualadh craicinn tearc a tha ann an 90 % de chùisean co-cheangailte ri rianachd cungaidh‑leigheis. Tha Acute generalized exanthematous pustulosis air a chomharrachadh le sprèadh craicinn obann a nochdas gu cuibheasach taobh a-staigh còig latha às deidh tòiseachadh cungaidh‑leigheis. Tha pustules ann an na sprèadhan sin, i.e. sprèadh beag dearg‑geal no dearg air a bheil stuth sgòthach no purulent (pus). Mar as trice, bidh lotan craicinn a’ fuasgladh taobh a-staigh 1‑3 latha bho stad a’ chungaidh‑leigheis oilbheumach.
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Bidh leòintean farsaing le erythema agus pustules a’ nochdadh gu h-obann.
relevance score : -100.0%
ReferencesIs e ath-bhualadh craiceann a th’ ann an Acute generalized exanthematous pustulosis (AGEP), a tha air a chomharrachadh le cnapan beaga làn pus air bonn craiceann dearg. Mar as trice, bidh e a’ tachairt nuair a bheir cuideigin cungaidhean sònraichte, leithid antibiotics, agus gu luath a’ sgaoileadh air feadh a’ chuirp. Às deidh stad a chur air a’ chungaidh‑leigheis brosnachaidh, bidh na comharraidhean gu tric a’ falbh taobh a-staigh dà sheachdain, a’ fàgail beagan rùsgadh craiceann. Ged nach àbhaist dhaibh a bhith dona agus cuingealaichte ris a’ chraiceann, faodar cùisean cruaidh a chomharrachadh, leithid droch ath‑bhualaidhean craiceann mar Stevens‑Johnson syndrome no toxic epidermal necrolysis. Tha làimhseachadh a’ gabhail a-steach cùram taiceil mòr, agus mar as trice, tha an prognosis airson fuasgladh iomlan den ghalar sàr‑mhath.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
Thàinig fireannach, 76, dhan t-seòmar-èiginn leis gu robh a chraiceann air atharrachadh thairis air an dà latha a dh'fhalbh. Lorg dotairean badan dearga agus raointean àrdaichte air a stoc agus a ghàirdeanan agus a chasan. Mar a chaidh an ùine air adhart, thàinig na pìosan sin còmhla, agus leasaich e cnapan coltach ri pimple anns na raointean dearga. Sheall deuchainnean cunntadh ceallan fala geal àrd le tòrr de sheòrsa ris an canar neutrophils, agus ìrean nas àirde de C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
