Amyloidosis
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Feartan aghaidh clasaigeach aig Amyloidosis
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ReferencesThàinig boireannach 26-bliadhna a-steach gu clìnic againn a’ gearan mu dheidhinn brod tachaiseach air a casan a bha i air a bhith ann airson 10 bliadhna. A dh'aindeoin a bhith a' cleachdadh uachdaran steroid agus uachdar tazarotene, cha do dh'fhàs am brod na b'fheàrr. Cha robh eachdraidh teaghlaich iomchaidh sam bith aice. Nuair a rinn sinn sgrùdadh oirre, lorg sinn badan àrda, garbh air beulaibh a casan, a tha a rèir galar ris an canar lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
A 26-year-old woman presented to our clinic with an itchy rash on her legs that had persisted for 10 years. The rash had previously been treated with topical steroids and tazarotene cream, with no improvement. The patient’s family history was noncontributory. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces, consistent with lichen amyloidosis.
Is e suidheachadh craiceann tearc a tha ann an Lichen Amyloidosis a tha co-cheangailte ri itching leantainneach gun adhbhar aithnichte. Mar as trice, bidh e a’ nochdadh mar chlàran de phìosan àrdaichte, dathach air uachdar a-muigh a’ chraicinn. Mar as trice, bidh Lichen Amyloidosis a’ nochdadh ann an daoine eadar aois 50 is 60 agus, gu mì-fhortanach, chan eil leigheas ann airson a. Gu tric, chan eil an làimhseachadh a tha ri fhaighinn an-dràsta ag obair gu math.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Lichen Amyloidosis (LA) is an uncommon, primary cutaneous amyloidosis associated with chronic, idiopathic pruritus. Clinical presentation of LA includes skin colored to hyperpigmented, papules coalescing into plaques with a rippled appearance on the extensors.1 LA most commonly presents in the fifth to sixth decade of life and has no curative treatments. Overall response to current therapies is poor.
Tha Lichen amyloidosis na staid prùineach a’ chraicinn fad-ùine. Tha e ainmeil airson cruinneachaidhean de chnapan tiugh a lorgar gu h-àraidh air a’ chùl, na shins, na sliasaid, agus na gàirdeanan. Nuair a thèid a sgrùdadh fo mhicroscop, tha Lichen amyloidosis a’ sealltainn cruinneachadh de amyloid anns an t-sreath as àirde den chraiceann, còmhla ri tiugh agus leudachadh air còmhdach a’ chraicinn a-muigh. Ged nach eil fìor adhbhar Lichen amyloidosis air a thuigsinn fhathast, tha sgrùdaidhean roimhe a’ ceangal ri factaran mar suathadh no suathadh air a’ chraiceann, bàs cealla, galairean virotach, am measg feadhainn eile. Tha e coltach gu bheil Lichen amyloidosis ceangailte ri grunn shuidheachaidhean craiceann eile (atopic dermatitis, lichen planus, mycosis fungoides).
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
Lichen amyloidosis (LA) is a chronic pruritic skin disorder characterized by multiple grouped hyperkeratotic papules, predominantly located on the back, shins, thighs, and arms. Histological analysis of LA shows amyloid deposition in the papillary dermis and hyperkeratosis and acanthosis of the epidermis. The exact pathogenesis of LA has not yet been elucidated; however, prior reports have implicated frictional epidermal damage, apoptosis, viral infection, and many other triggers. LA is reportedly associated with several skin disorders, including atopic dermatitis (AD), lichen planus, and mycosis fungoides.
○ Diagnosadh agus Làimhseachadh
#Electrophoresis of blood or urine
#Skin biopsy