Onychomysosis
☆ Ann an toraidhean 2022 Stiftung Warentest às a’ Ghearmailt, cha robh sàsachd luchd-cleachdaidh le ModelDerm ach beagan nas ìsle na le co-chomhairlean telemedicine pàighte.
Toenail fo bhuaidh Onychomysosis
Cas neach le galar fungach ìnean deich seachdainean a-steach do chùrsa de chungaidh-leigheis beòil terbinafine. Thoir an aire don chòmhlan de fhàs fallain ìnean air cùl na h-ìnean gabhaltach a tha air fhàgail.
References
Is e antifungals siostamach an làimhseachadh as èifeachdaiche. Tha meta-anailisean a’ sealltainn ìrean leigheis mycotic mar a leanas: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48% . Bidh debridement ìnean concomitant ag àrdachadh ìrean leigheis tuilleadh. Chan eil leigheas cuspaireil le ciclopirox cho èifeachdach; tha ìre fàilligeadh aige nas àirde na 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Systemic antifungals are the most effective treatment. Meta-analyses shows mycotic cure rates as follows: terbinafine = 76%, itraconazole with pulse dosing = 63%, itraconazole with continuous dosing = 59%, fluconazole =48%. Concomitant nail debridement further increases cure rates. Topical therapy with ciclopirox is less effective; it has a failure rate exceeding 60%.
Tha onychomycosis na ghalar fungach a bheir buaidh air na h-ìnean. Nuair a tha e air adhbhrachadh le dermatophytes, canar tinea unguium ris. Tha onychomycosis a’ toirt a-steach galairean air adhbhrachadh le dermatophytes, beirm, agus molltair. Canar nail dystrophy ri duilgheadas ìnean nach eil air adhbhrachadh le galar fungach. Ged a dh’ fhaodadh e buaidh a thoirt air an dà chuid ìnean agus ìnean, tha onychomycosis toenail nas cumanta. Tha an artaigil seo a’ beachdachadh air diofar thaobhan de onychomycosis toenail, leithid a bhuaidh, seòrsachan clionaigeach, ìrean, breithneachadh agus làimhseachadh. Ged nach eil e na chunnart do bheatha, faodaidh onychomycosis leantainn gu fìor dhuilgheadasan leithid cellulitis, sepsis, galar cnàimh, milleadh clò, agus call ìnean.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Onychomycosis is a fungal infection of the nail unit. When dermatophytes cause onychomycosis, this condition is called tinea unguium. The term onychomycosis encompasses the dermatophytes, yeasts, and saprophytic mold infections. An abnormal nail not caused by a fungal infection is a dystrophic nail. Onychomycosis can infect both fingernails and toenails, but onychomycosis of the toenail is much more prevalent. Discussed in detail in this activity are all evolving facets of the topic, including disease burden, clinical types, staging, diagnosis, and management of toenail onychomycosis. While non-life-threatening, onychomycosis can lead to severe complications such as cellulitis, sepsis, osteomyelitis, tissue damage, and nail loss.
Is e cungaidh-leigheis a th’ ann an Terbinafine a bhios a’ cuir an-aghaidh galairean fungach le bhith a’ bacadh squalene epoxidase. Tha e èifeachdach an aghaidh iomadh seòrsa fungas craiceann agus tha e air aontachadh airson fungas ìnean a làimhseachadh nuair a thèid a thogail beòil. Ged a tha a’ mhòr-chuid de bhuaidhean leithid ceann goirt agus cùisean stamag beag agus a’ falbh leotha fhèin, faodaidh atharrachaidhean ann am blas (dysgeusia) atharrachadh bho bhith tlàth gu dona, uaireannan a’ leantainn gu call cuideim. Tha atharrachaidhean blas maireannach gu math tearc ach chaidh aithris.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Terbinafine is an antifungal medication that works through the inhibition of squalene epoxidase. It has activity against most dermatophytes, and it has approval for use as an oral therapy for the treatment of onychomycosis. Although most side effects are mild and self-limited, such as headache and gastrointestinal symptoms, taste disturbances (dysgeusia) can range from mild to severe, resulting in weight loss, and have rarely been reported permanent.
Tha onychomycosis na ghalar fungach a bheir buaidh air ìnean. Tha timcheall air 90% de ghalaran toenail agus 75% de ghalaran meòir air adhbhrachadh le fungasan (Trichophyton mentagrophytes, Trichophyton rubrum) . Tha comharran a’ toirt a-steach dath dath nan ìnean, tiughachadh, dealachadh bhon leabaidh ìnean, agus cus fhàs. Mar as trice bidh làimhseachadh a’ toirt a-steach cungaidhean beòil leithid terbinafine no itraconazole, le làimhseachadh gnàthach mar roghainn airson cùisean tlàth gu meadhanach.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis.
Tha e coltach gur e an terbinafine cungaidh-leigheis antifungal a thèid a thoirt leis a’ bheul as èifeachdaiche ach tha terbinafine co-cheangailte ri taobh-buaidh ae.
Tha onychomysosis a’ tachairt ann an timcheall air 10 sa cheud den t-sluagh inbheach, le daoine nas sine a’ toirt buaidh nas trice. Bidh an fheadhainn fhireann a’ toirt buaidh nas trice na boireannaich. Tha onychomysosis a’ riochdachadh mu leth den ghalar ìnean. Tha seo a’ ciallachadh gum faod deformity nan òrdagan cuideachd tighinn bho adhbharan a bharrachd air onychomycosis.
○ Làimhseachadh - Drogaichean OTC
Tha e duilich onychomycosis a làimhseachadh le cungaidhean gnàthach oir tha e duilich do dhrogaichean a dhol a-steach do na h-ìnean tiugh.
#Ketoconazole
#Clotrimazole
#Miconazole
#Terbinafine
#Butenafine [Lotrimin]
#Tolnaftate
○ làimhseachadh
Mar as trice bidh feum air làimhseachadh fad-ùine gus an tèid an toenail gabhaltach a thoirt air falbh gu tur.
#Terbinafine (oral)
#Itraconazole
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer